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rdf:type
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Description
| - A minimally deleted region of chromoseme 17p in DLBCLs encompassing approximatelly 0.8 MB telomeric to TP53 locus was defined. This genomic region harbors the tumor suppressor Hyper methylated in Cancer 1 (HIC1). HIC1 exon 1a is hypermethylated in a substantial subset of DLBCLs, whic is accompanied by simultaneous HIC1 deletion of the second allele in 90% of cases. DLBCL patients with complete inactivation of both HIC1 and TP53 may be characterized by an even inferior clinical course than patients with inactivation of TP53 alone, suggesting a functional cooperation between these two proteins..
- A minimally deleted region of chromoseme 17p in DLBCLs encompassing approximatelly 0.8 MB telomeric to TP53 locus was defined. This genomic region harbors the tumor suppressor Hyper methylated in Cancer 1 (HIC1). HIC1 exon 1a is hypermethylated in a substantial subset of DLBCLs, whic is accompanied by simultaneous HIC1 deletion of the second allele in 90% of cases. DLBCL patients with complete inactivation of both HIC1 and TP53 may be characterized by an even inferior clinical course than patients with inactivation of TP53 alone, suggesting a functional cooperation between these two proteins.. (en)
- Byla definována minimální oblast deletovaná na chromosomu 17p u DLBCL, která je rozsáhlá asi 0,8 MB a je lokalizovaná telomericky vzhledem k TP53. V této genomické oblasti je umístěn nádorový supresor HIC1 (Hypermethylated in Cancer 1). Exon 1a genu HIC1 je hypermetylován u významného podílu DLBCL, což je u 90% případů doprovázeno simultánní delecí druhé alely. Průběh onemocnění u pacientů s kompletní inaktivací jak HIC1 tak TP53 je závažnější než u pacientů se ztrátou pouze TP53. To svědčí o funkční kooperaci obou proteinů. (cs)
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Title
| - Detailed mapping of chromosome 17p deletions reveales HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma
- Detailed mapping of chromosome 17p deletions reveales HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma (en)
- Podrobné mapování delecí chromosomu 17p odhalilo HIC1 jako kandidáta na nový nádorový supresor lokalizovaný v telomerické pozici vzhledem k p53 u difúzního velkobuněčného B lymfomu (cs)
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skos:prefLabel
| - Detailed mapping of chromosome 17p deletions reveales HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma
- Detailed mapping of chromosome 17p deletions reveales HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma (en)
- Podrobné mapování delecí chromosomu 17p odhalilo HIC1 jako kandidáta na nový nádorový supresor lokalizovaný v telomerické pozici vzhledem k p53 u difúzního velkobuněčného B lymfomu (cs)
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skos:notation
| - RIV/65269705:_____/08:#0000137!RIV09-MZ0-65269705
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/65269705:_____/08:#0000137
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - diffuse large B-cell lymphoma; del(17p); TP53 (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Šmardová, Jana
- Mačák, Jirka
- Stocklein, Heike
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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