About: Detailed mapping of chromosome 17p deletions reveales HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma     Goto   Sponge   NotDistinct   Permalink

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  • A minimally deleted region of chromoseme 17p in DLBCLs encompassing approximatelly 0.8 MB telomeric to TP53 locus was defined. This genomic region harbors the tumor suppressor Hyper methylated in Cancer 1 (HIC1). HIC1 exon 1a is hypermethylated in a substantial subset of DLBCLs, whic is accompanied by simultaneous HIC1 deletion of the second allele in 90% of cases. DLBCL patients with complete inactivation of both HIC1 and TP53 may be characterized by an even inferior clinical course than patients with inactivation of TP53 alone, suggesting a functional cooperation between these two proteins..
  • A minimally deleted region of chromoseme 17p in DLBCLs encompassing approximatelly 0.8 MB telomeric to TP53 locus was defined. This genomic region harbors the tumor suppressor Hyper methylated in Cancer 1 (HIC1). HIC1 exon 1a is hypermethylated in a substantial subset of DLBCLs, whic is accompanied by simultaneous HIC1 deletion of the second allele in 90% of cases. DLBCL patients with complete inactivation of both HIC1 and TP53 may be characterized by an even inferior clinical course than patients with inactivation of TP53 alone, suggesting a functional cooperation between these two proteins.. (en)
  • Byla definována minimální oblast deletovaná na chromosomu 17p u DLBCL, která je rozsáhlá asi 0,8 MB a je lokalizovaná telomericky vzhledem k TP53. V této genomické oblasti je umístěn nádorový supresor HIC1 (Hypermethylated in Cancer 1). Exon 1a genu HIC1 je hypermetylován u významného podílu DLBCL, což je u 90% případů doprovázeno simultánní delecí druhé alely. Průběh onemocnění u pacientů s kompletní inaktivací jak HIC1 tak TP53 je závažnější než u pacientů se ztrátou pouze TP53. To svědčí o funkční kooperaci obou proteinů. (cs)
Title
  • Detailed mapping of chromosome 17p deletions reveales HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma
  • Detailed mapping of chromosome 17p deletions reveales HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma (en)
  • Podrobné mapování delecí chromosomu 17p odhalilo HIC1 jako kandidáta na nový nádorový supresor lokalizovaný v telomerické pozici vzhledem k p53 u difúzního velkobuněčného B lymfomu (cs)
skos:prefLabel
  • Detailed mapping of chromosome 17p deletions reveales HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma
  • Detailed mapping of chromosome 17p deletions reveales HIC1 as a novel tumor suppressor gene candidate telomeric to TP53 in diffuse large B-cell lymphoma (en)
  • Podrobné mapování delecí chromosomu 17p odhalilo HIC1 jako kandidáta na nový nádorový supresor lokalizovaný v telomerické pozici vzhledem k p53 u difúzního velkobuněčného B lymfomu (cs)
skos:notation
  • RIV/65269705:_____/08:#0000137!RIV09-MZ0-65269705
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR9305)
http://linked.open...iv/cisloPeriodika
  • 18
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 362770
http://linked.open...ai/riv/idVysledku
  • RIV/65269705:_____/08:#0000137
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • diffuse large B-cell lymphoma; del(17p); TP53 (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [365813FC3A91]
http://linked.open...i/riv/nazevZdroje
  • Oncogene
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 27
http://linked.open...iv/tvurceVysledku
  • Šmardová, Jana
  • Mačák, Jirka
  • Stocklein, Heike
http://linked.open...ain/vavai/riv/wos
  • 000255057000011
issn
  • 0950-9232
number of pages
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