About: Low antigen-dependent activity of T cells after repeated stimulation using dendritic cells and expansion with interleukin-2

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About: Low antigen-dependent activity of T cells after repeated stimulation using dendritic cells and expansion with interleukin-2 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Both CD 8+ and CD 4+ T cells with specific activity against tumor antigens are needed for an efficient antitumor immune response. Activation snd proliferation of T cells require cellular interactions including adhesion,recognition of peptides presented by MHC molecules to the T cells receptor, and costimulation. In a series of experiments we attempted to generate and expand specific T cells by repeated stimulation using antigen-loaded autologous dendritic cells (DCs). Dcs werwobtained from peripheral blood mononuclear cells (PBMC) in the presence of IL ? 4 and GM-CSF. TNF ?á was added to induce maturation. A conjugate of myeloma idiotypic protein wih keyhole limpet hemocyanin was used as antigen. Nonadherent peripheral blood mononuclear cells were cultured in the presence of IL-2 and IL-7. Autologous DCs were added to the lymphocyte on days 3,10, and17. The lymphocytes were stimulated by high concentration of IL-2 between days 21 and 27. Lymphocytes harvested on day 27 proliferated in response to anit Both CD 8+ and CD 4+ T cells with specific activity against tumor antigens are needed for an efficient antitumor immune response. Activation snd proliferation of T cells require cellular interactions including adhesion,recognition of peptides presented by MHC molecules to the T cells receptor, and costimulation. In a series of experiments we attempted to generate and expand specific T cells by repeated stimulation using antigen-loaded autologous dendritic cells (DCs). Dcs werwobtained from peripheral blood mononuclear cells (PBMC) in the presence of IL ? 4 and GM-CSF. TNF ?á was added to induce maturation. A conjugate of myeloma idiotypic protein wih keyhole limpet hemocyanin was used as antigen. Nonadherent peripheral blood mononuclear cells were cultured in the presence of IL-2 and IL-7. Autologous DCs were added to the lymphocyte on days 3,10, and17. The lymphocytes were stimulated by high concentration of IL-2 between days 21 and 27. Lymphocytes harvested on day 27 proliferated in response to anit (en)
Title	Low antigen-dependent activity of T cells after repeated stimulation using dendritic cells and expansion with interleukin-2 Low antigen-dependent activity of T cells after repeated stimulation using dendritic cells and expansion with interleukin-2 (en)
skos:prefLabel	Low antigen-dependent activity of T cells after repeated stimulation using dendritic cells and expansion with interleukin-2 Low antigen-dependent activity of T cells after repeated stimulation using dendritic cells and expansion with interleukin-2 (en)
skos:notation	RIV/65269705:_____/03:00007983!RIV/2004/MZ0/L43004/N
http://linked.open.../vavai/riv/strany	120-123
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(NC6763)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Büchler, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Fakultní nemocnice Brno / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	613910
http://linked.open...ai/riv/idVysledku	RIV/65269705:_____/03:00007983
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	T cells;dendritic cells;immunotherapy;in vitor cell culture (en)
http://linked.open.../riv/klicoveSlovo	immunotherapy dendritic cells T cells in vitor cell culture
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[6E5FB342AAD5]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	9 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Use of monoclonal immunoglobulin for preparation of antitumor vaccine in patients with multiple myeloma
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	50
http://linked.open...iv/tvurceVysledku	Büchler, Tomáš
issn	0028-2685
number of pages	4 (xsd:int)

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