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Description
| - The chromatographic behavior was studied of a series of potential acetylcholinesterase reactivators, pyridinium oximes, bearing linear aliphatic chains of the length of the aliphatic bridge from 1 to 12 carbon atoms, on a pentafluorophenyl-modified stationary phase. The retention mechanisms and the dependence of the capacity factor on mobile phase composition, aliphatic chain bridge length and calculated log P were evaluated and discussed in detail. The separation of the studied oximes was found to be driven by hydrophobic interactions when a lower content of organic modifier was used in mobile phase; however, the ion-exchange mechanism was the leading one when a large portion of organic modifier was used. In addition, the lipophilicity was found to be a driving mechanism of the separation of oximes bearing a connecting chain of the length of 6-12 carbon atoms, whereas the retention of oximes with shorter connecting chains was significantly influenced by other separation mechanisms such as aromatic or pi-pi interaction. These results can be useful for the development of new, efficient acetylcholinesterase reactivators.
- The chromatographic behavior was studied of a series of potential acetylcholinesterase reactivators, pyridinium oximes, bearing linear aliphatic chains of the length of the aliphatic bridge from 1 to 12 carbon atoms, on a pentafluorophenyl-modified stationary phase. The retention mechanisms and the dependence of the capacity factor on mobile phase composition, aliphatic chain bridge length and calculated log P were evaluated and discussed in detail. The separation of the studied oximes was found to be driven by hydrophobic interactions when a lower content of organic modifier was used in mobile phase; however, the ion-exchange mechanism was the leading one when a large portion of organic modifier was used. In addition, the lipophilicity was found to be a driving mechanism of the separation of oximes bearing a connecting chain of the length of 6-12 carbon atoms, whereas the retention of oximes with shorter connecting chains was significantly influenced by other separation mechanisms such as aromatic or pi-pi interaction. These results can be useful for the development of new, efficient acetylcholinesterase reactivators. (en)
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Title
| - Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography
- Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography (en)
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skos:prefLabel
| - Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography
- Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography (en)
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skos:notation
| - RIV/62690094:18470/14:50002315!RIV15-MSM-18470___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/62690094:18470/14:50002315
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - high-performance liquid chromatography; stationary phase; PFP; pyridinium oximes; Retention behavior (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Journal of chromatographic science
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Dohnal, Vlastimil
- Kuča, Kamil
- Musílek, Kamil
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http://linked.open...ain/vavai/riv/wos
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issn
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number of pages
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http://bibframe.org/vocab/doi
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http://localhost/t...ganizacniJednotka
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