About: Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography

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About: Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The chromatographic behavior was studied of a series of potential acetylcholinesterase reactivators, pyridinium oximes, bearing linear aliphatic chains of the length of the aliphatic bridge from 1 to 12 carbon atoms, on a pentafluorophenyl-modified stationary phase. The retention mechanisms and the dependence of the capacity factor on mobile phase composition, aliphatic chain bridge length and calculated log P were evaluated and discussed in detail. The separation of the studied oximes was found to be driven by hydrophobic interactions when a lower content of organic modifier was used in mobile phase; however, the ion-exchange mechanism was the leading one when a large portion of organic modifier was used. In addition, the lipophilicity was found to be a driving mechanism of the separation of oximes bearing a connecting chain of the length of 6-12 carbon atoms, whereas the retention of oximes with shorter connecting chains was significantly influenced by other separation mechanisms such as aromatic or pi-pi interaction. These results can be useful for the development of new, efficient acetylcholinesterase reactivators. The chromatographic behavior was studied of a series of potential acetylcholinesterase reactivators, pyridinium oximes, bearing linear aliphatic chains of the length of the aliphatic bridge from 1 to 12 carbon atoms, on a pentafluorophenyl-modified stationary phase. The retention mechanisms and the dependence of the capacity factor on mobile phase composition, aliphatic chain bridge length and calculated log P were evaluated and discussed in detail. The separation of the studied oximes was found to be driven by hydrophobic interactions when a lower content of organic modifier was used in mobile phase; however, the ion-exchange mechanism was the leading one when a large portion of organic modifier was used. In addition, the lipophilicity was found to be a driving mechanism of the separation of oximes bearing a connecting chain of the length of 6-12 carbon atoms, whereas the retention of oximes with shorter connecting chains was significantly influenced by other separation mechanisms such as aromatic or pi-pi interaction. These results can be useful for the development of new, efficient acetylcholinesterase reactivators. (en)
Title	Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography (en)
skos:prefLabel	Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography Retention behavior of pyridinium oximes on PFP stationary phase in high-performance liquid chromatography (en)
skos:notation	RIV/62690094:18470/14:50002315!RIV15-MSM-18470___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Dohnal, Vlastimil Kuča, Kamil Musílek, Kamil
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Hradec Králové / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	42542
http://linked.open...ai/riv/idVysledku	RIV/62690094:18470/14:50002315
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	high-performance liquid chromatography; stationary phase; PFP; pyridinium oximes; Retention behavior (en)
http://linked.open.../riv/klicoveSlovo	Retention behavior high-performance liquid chromatography stationary phase pyridinium oximes PFP
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C0A1A65E5C4F]
http://linked.open...i/riv/nazevZdroje	Journal of chromatographic science
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	52
http://linked.open...iv/tvurceVysledku	Dohnal, Vlastimil Kuča, Kamil Musílek, Kamil
http://linked.open...ain/vavai/riv/wos	000342734000009
issn	0021-9665
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/chromsci/bmt019
http://localhost/t...ganizacniJednotka	18470

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