About: Binding of naturally occurring hydroxycinnamic acids to bovine serum albumin

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Hydroxycinnamic acids (HCAs) possess numerous biological and due to these properties are widely used in folk medicine. Nevertheless, they can interact with protein molecules and cause some structural and functional changes. The possibility of HCAs binding to bovine serum albumin (BSA) under physiological conditions was investigated by the UV-VIS absorption spectroscopy, fluorescence quenching method, and FRET method. The binding constants, number of binding sites and free energy changes were determined. The binding affinities of HCAs were ranked in the order: chlorogenic acid > sinapic acid >= caffeic acid > ferulic acid > o-coumaric acid > p-coumaric acid >= m-coumaric acid, which was confirmed by spectral overlaps of BSA emission spectrum with absorption spectrum of HCA. All free energy changes possessed negative sign indicating the spontaneity of HCA-BSA interaction. Hydroxycinnamic acids (HCAs) possess numerous biological and due to these properties are widely used in folk medicine. Nevertheless, they can interact with protein molecules and cause some structural and functional changes. The possibility of HCAs binding to bovine serum albumin (BSA) under physiological conditions was investigated by the UV-VIS absorption spectroscopy, fluorescence quenching method, and FRET method. The binding constants, number of binding sites and free energy changes were determined. The binding affinities of HCAs were ranked in the order: chlorogenic acid > sinapic acid >= caffeic acid > ferulic acid > o-coumaric acid > p-coumaric acid >= m-coumaric acid, which was confirmed by spectral overlaps of BSA emission spectrum with absorption spectrum of HCA. All free energy changes possessed negative sign indicating the spontaneity of HCA-BSA interaction. (en)
Title	Binding of naturally occurring hydroxycinnamic acids to bovine serum albumin Binding of naturally occurring hydroxycinnamic acids to bovine serum albumin (en)
skos:prefLabel	Binding of naturally occurring hydroxycinnamic acids to bovine serum albumin Binding of naturally occurring hydroxycinnamic acids to bovine serum albumin (en)
skos:notation	RIV/62690094:18470/10:00003037!RIV11-MSM-18470___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	2(6)
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Dršata, Jaroslav Trnková, Lucie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Hradec Králové / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	248814
http://linked.open...ai/riv/idVysledku	RIV/62690094:18470/10:00003037
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	bovine serum albumin; hydroxycinnamic acid; fluorescence quenching; protein-ligand binding (en)
http://linked.open.../riv/klicoveSlovo	bovine serum albumin fluorescence quenching hydroxycinnamic acid protein-ligand binding
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[2D3CB1DD3DE4]
http://linked.open...i/riv/nazevZdroje	Natural science
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	7
http://linked.open...iv/tvurceVysledku	Boušová, Iva Dršata, Jaroslav Trnková, Lucie Kubíček, Vladimír
issn	2150-4091
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	18470

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