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  • Deoxynivalenol (DON) is one of the most abundant mycotoxins in contaminated food and feed worldwide. It is toxic to humans and inhibits DNA, RNA and protein synthesis. In this review, the metabolism of DON and its exposure in humans from different regions are summarized. Conjugated products DON-3-glucuronide, DON-15-glucuronide, and DON-7-glucuronide are found to be the major metabolites in humans. Human exposure of DON shows some regional differences due to the different DON levels in cereal-based foods and the food intake habits. C12,13-deepoxy metabolite, DOM-1 can be found in most French populations but is rarely detected in UK adults. Spanish exposes lower DON levels than the UK populations. A very high DON exposure is detected in South Africa and Linxian, China. Fetus is shown to expose to DON during pregnancy in human. This review will provide global information of DON metabolism and exposure in humans and facilitate the mycotoxin control strategies.
  • Deoxynivalenol (DON) is one of the most abundant mycotoxins in contaminated food and feed worldwide. It is toxic to humans and inhibits DNA, RNA and protein synthesis. In this review, the metabolism of DON and its exposure in humans from different regions are summarized. Conjugated products DON-3-glucuronide, DON-15-glucuronide, and DON-7-glucuronide are found to be the major metabolites in humans. Human exposure of DON shows some regional differences due to the different DON levels in cereal-based foods and the food intake habits. C12,13-deepoxy metabolite, DOM-1 can be found in most French populations but is rarely detected in UK adults. Spanish exposes lower DON levels than the UK populations. A very high DON exposure is detected in South Africa and Linxian, China. Fetus is shown to expose to DON during pregnancy in human. This review will provide global information of DON metabolism and exposure in humans and facilitate the mycotoxin control strategies. (en)
Title
  • DEOXYNIVALENOL: METABOLISM AND REGIONAL DIFFERENCES IN HUMAN EXPOSURE
  • DEOXYNIVALENOL: METABOLISM AND REGIONAL DIFFERENCES IN HUMAN EXPOSURE (en)
skos:prefLabel
  • DEOXYNIVALENOL: METABOLISM AND REGIONAL DIFFERENCES IN HUMAN EXPOSURE
  • DEOXYNIVALENOL: METABOLISM AND REGIONAL DIFFERENCES IN HUMAN EXPOSURE (en)
skos:notation
  • RIV/62690094:18450/14:50002641!RIV15-MSM-18450___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
  • Wu, Qinghua
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 10241
http://linked.open...ai/riv/idVysledku
  • RIV/62690094:18450/14:50002641
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • DON-15-glucuronide; DON-3-glucuronide; exposure; human; metabolism; DON; Deoxynivalenol (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [09F0A0E02C4B]
http://linked.open...i/riv/nazevZdroje
  • Vojenské zdravotnické listy=Military medical science letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 83
http://linked.open...iv/tvurceVysledku
  • Wu, Qinghua
  • Yuan, Zong-Hui
  • Zhang, Xiu-Juan
  • Wan, Dan
  • Wang, Yun
  • Wu, Guang-Xu
issn
  • 0372-7025
number of pages
http://localhost/t...ganizacniJednotka
  • 18450
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