About: Genetics of anti-EHV antibody responses in a horse population

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p { 0.001) in antibody titers between two color varieties of Old Kladruber horses, separate association studies were performed in the two sub-populations by using the Fisher's exact test. In black horses, the interleukin 4 receptor and MxA protein coding genes, and the microsatellite TKY325 were associated with the responder status. In the grey population, the microsatellite TKY343 showed significant association with anti-EHV antibody responsiveness after Bonferroni corrections. Individual variation in immune responses to herpesviruses was observed in various species. Here, associations between polymorphic molecular markers and life-long anti-EHV-1/4 antibody immune responses were analyzed in a model EHV-infected population of the Old Kladruber horses. Two-dimensional analysis including overall mean titers and titer dynamics expressed by differences between spring and autumn titers allowed identification of low-responders. 50 randomly selected microsatellites and nine single nucleotide polymorphisms in nine immunity-related candidate genes were genotyped. Due to differences (p { 0.001) in antibody titers between two color varieties of Old Kladruber horses, separate association studies were performed in the two sub-populations by using the Fisher's exact test. In black horses, the interleukin 4 receptor and MxA protein coding genes, and the microsatellite TKY325 were associated with the responder status. In the grey population, the microsatellite TKY343 showed significant association with anti-EHV antibody responsiveness after Bonferroni corrections. (en)
Title	Genetics of anti-EHV antibody responses in a horse population Genetics of anti-EHV antibody responses in a horse population (en)
skos:prefLabel	Genetics of anti-EHV antibody responses in a horse population Genetics of anti-EHV antibody responses in a horse population (en)
skos:notation	RIV/62157124:16810/13:43872343!RIV14-MZE-16810___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(GA523/09/1972), P(QH92265), P(QH92277)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Celer, Vladimír Molinková, Dobromila
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Rektorát
http://linked.open...dnocenehoVysledku	76409
http://linked.open...ai/riv/idVysledku	RIV/62157124:16810/13:43872343
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Statistical associations; Microsatellites; Immunity-related molecular markers; Antibody responsiveness; Equine herpes virus (en)
http://linked.open.../riv/klicoveSlovo	Microsatellites Antibody responsiveness Equine herpes virus Immunity-related molecular markers Statistical associations
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[6AB277B3E1E0]
http://linked.open...i/riv/nazevZdroje	Research in Veterinary Science
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic diversity and its conservation in selected horse populations in the Czech Republic Central european institute of technology Optimization of breeding system and health care in endangered breed of Old Kladruby horse Comparative immunogenomics of the family Equidae
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	95
http://linked.open...iv/tvurceVysledku	Dušek, Ladislav Putnová, Lenka Vrtková, Irena Mužík, Jan Celer, Vladimír Hořín, Petr Sedlinská, Markéta Molinková, Dobromila Klumplerová, Marie Rusek, Jakub
http://linked.open...ain/vavai/riv/wos	000320289600022
issn	0034-5288
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.rvsc.2013.03.011
http://localhost/t...ganizacniJednotka	16810

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