About: Rapid Informative Screening of Nano-Alaptide as Potential Transdermal Permeation Enhancer of Acetylsalicylic Acid and Paracetamol.     Goto   Sponge   NotDistinct   Permalink

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  • This investigation deals with the affection of permeation of acetylsalicylic acid and paracetamol applied in the system propylene glycol-water 1:1 through full-thickness pig ear skin by alaptide that was applied in nanonized form as a potential chemical penetration enhancer. Alaptide, (S)-8-methyl-6,9- diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. The application of nanonized alaptide significantly enhanced the permeation of both drugs through the skin. Enhancement ratios in the studied time interval 0.5-2.0 h varied from 1.11 to 17.70 for acetylsalicylic acid and from 6.83 to 19.83 for paracetamol.
  • This investigation deals with the affection of permeation of acetylsalicylic acid and paracetamol applied in the system propylene glycol-water 1:1 through full-thickness pig ear skin by alaptide that was applied in nanonized form as a potential chemical penetration enhancer. Alaptide, (S)-8-methyl-6,9- diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. The application of nanonized alaptide significantly enhanced the permeation of both drugs through the skin. Enhancement ratios in the studied time interval 0.5-2.0 h varied from 1.11 to 17.70 for acetylsalicylic acid and from 6.83 to 19.83 for paracetamol. (en)
Title
  • Rapid Informative Screening of Nano-Alaptide as Potential Transdermal Permeation Enhancer of Acetylsalicylic Acid and Paracetamol.
  • Rapid Informative Screening of Nano-Alaptide as Potential Transdermal Permeation Enhancer of Acetylsalicylic Acid and Paracetamol. (en)
skos:prefLabel
  • Rapid Informative Screening of Nano-Alaptide as Potential Transdermal Permeation Enhancer of Acetylsalicylic Acid and Paracetamol.
  • Rapid Informative Screening of Nano-Alaptide as Potential Transdermal Permeation Enhancer of Acetylsalicylic Acid and Paracetamol. (en)
skos:notation
  • RIV/62157124:16370/14:43873239!RIV15-GA0-16370___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GAP304/11/2246)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 41358
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16370/14:43873239
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  • paracetamol; acetylsalicylic acid; chemical penetration enhancer; nanoparticles; alaptide (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [913E46EFFE7D]
http://linked.open...i/riv/nazevZdroje
  • Vojenské zdravotnické listy - Military Medical Science Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 83
http://linked.open...iv/tvurceVysledku
  • Jampílek, Josef
  • Opatřilová, Radka
  • Černíková, Aneta
issn
  • 0372-7025
number of pages
http://localhost/t...ganizacniJednotka
  • 16370
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