About: The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart

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About: The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Motherwort (Leonurus cardiaca) possesses antibacterial, antioxidant, anti-inflammatory, and analgesic activities, and is used as a complementary remedy to improve heart function and blood circulation. Since cardiovascular diseases are often associated with an alteration of mitochondria, the main producers of ATP in cardiac muscle cells, the aim of work was to determine bioactive constituents present in motherwort aerial parts extract in ethanol and investigate their effects on the functions of cardiac mitochondria. The results showed that constituents (chlorogenic acid, orientin, quercetin, hyperoside, and rutin) of L.cardiaca herb extract uncouple (by 20-90%) mitochondrial oxidation from phosphorylation, partially inhibit (by similar to 40%) the mitochondrial respiratory chain in cases of pyruvate and malate as well as succinate oxidation, and effectively attenuate the generation of free radicals in mitochondria. Motherwort (Leonurus cardiaca) possesses antibacterial, antioxidant, anti-inflammatory, and analgesic activities, and is used as a complementary remedy to improve heart function and blood circulation. Since cardiovascular diseases are often associated with an alteration of mitochondria, the main producers of ATP in cardiac muscle cells, the aim of work was to determine bioactive constituents present in motherwort aerial parts extract in ethanol and investigate their effects on the functions of cardiac mitochondria. The results showed that constituents (chlorogenic acid, orientin, quercetin, hyperoside, and rutin) of L.cardiaca herb extract uncouple (by 20-90%) mitochondrial oxidation from phosphorylation, partially inhibit (by similar to 40%) the mitochondrial respiratory chain in cases of pyruvate and malate as well as succinate oxidation, and effectively attenuate the generation of free radicals in mitochondria. (en)
Title	The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart (en)
skos:prefLabel	The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart (en)
skos:notation	RIV/62157124:16370/14:43873139!RIV15-MSM-16370___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Masteiková, Ruta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	13375
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/14:43873139
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Leonurus cardiaca, Lamiaceae, flavonoid, polyphenol, oxidative phosphorylation, cardiac mitochondria (en)
http://linked.open.../riv/klicoveSlovo	oxidative phosphorylation flavonoid polyphenol Leonurus cardiaca Lamiaceae cardiac mitochondria
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[5D7A23333021]
http://linked.open...i/riv/nazevZdroje	Planta Medica
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	80
http://linked.open...iv/tvurceVysledku	Bernatoniene, Jurga Masteiková, Ruta Majiene, Daiva Savickas, Arunas Kopustinskiene, Dalia Marija Trumbeckaite, Sonata Baniene, Rasa Jakstas, Valdas Kuršvietiene, Lolita Toleikis, Adolfas
http://linked.open...ain/vavai/riv/wos	000336493000001
issn	0032-0943
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1055/s-0034-1368426
http://localhost/t...ganizacniJednotka	16370

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