About: In vitro antioxidant properties of novel Beta3-adrenoceptor agonists bearing benzenesulfonamide fragment

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	As an extension of our research, the in vitro antioxidant efficiency of perspective agonists of Beta3-adrenoceptors structurally based on the aryloxypropanolamine pharmacophore, chemically 3-{4- [(alkoxycarbonyl)amino]phenoxy}-N-{2-[4-(aminosulfonyl)phenyl]ethyl}-2-hydroxypropan-1-ammonium chlorides, was investigated. The potential of evaluated compounds to reduce relatively stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals in the spectrophotometric tests was dependent on the length of the alkyl substituent of alkoxycarbonylamino moiety directly attached to phenyl ring. The elongation of given string was accompanied by the increase in the effectiveness. From the entire analyzed set, the compound containing butoxycarbonylamino group has been able to act most markedly as the reduction agent towards the DPPH radicals showing the percentage of the DPPH reduction (% DPPH) of 11.34?0.02. On the other hand, the tested derivative has shown approximately ninefold decrease in the efficiency compared to applied Trolox standard, a water-soluble analogue of vitamin E, with its %DPPH=95.45?0.02. As an extension of our research, the in vitro antioxidant efficiency of perspective agonists of Beta3-adrenoceptors structurally based on the aryloxypropanolamine pharmacophore, chemically 3-{4- [(alkoxycarbonyl)amino]phenoxy}-N-{2-[4-(aminosulfonyl)phenyl]ethyl}-2-hydroxypropan-1-ammonium chlorides, was investigated. The potential of evaluated compounds to reduce relatively stable 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals in the spectrophotometric tests was dependent on the length of the alkyl substituent of alkoxycarbonylamino moiety directly attached to phenyl ring. The elongation of given string was accompanied by the increase in the effectiveness. From the entire analyzed set, the compound containing butoxycarbonylamino group has been able to act most markedly as the reduction agent towards the DPPH radicals showing the percentage of the DPPH reduction (% DPPH) of 11.34?0.02. On the other hand, the tested derivative has shown approximately ninefold decrease in the efficiency compared to applied Trolox standard, a water-soluble analogue of vitamin E, with its %DPPH=95.45?0.02. (en)
Title	In vitro antioxidant properties of novel Beta3-adrenoceptor agonists bearing benzenesulfonamide fragment In vitro antioxidant properties of novel Beta3-adrenoceptor agonists bearing benzenesulfonamide fragment (en)
skos:prefLabel	In vitro antioxidant properties of novel Beta3-adrenoceptor agonists bearing benzenesulfonamide fragment In vitro antioxidant properties of novel Beta3-adrenoceptor agonists bearing benzenesulfonamide fragment (en)
skos:notation	RIV/62157124:16370/13:43872462!RIV14-MSM-16370___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Csöllei, Jozef Muselík, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	79398
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/13:43872462
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Lipophilicity; Antioxidant properties; Beta3-adrenoceptor agonists (en)
http://linked.open.../riv/klicoveSlovo	Antioxidant properties Beta3-adrenoceptor agonists Lipophilicity
http://linked.open...odStatuVydavatele	BD - Bangladéšská lidová republika
http://linked.open...ontrolniKodProRIV	[EC7A1BEAB221]
http://linked.open...i/riv/nazevZdroje	Dhaka University Journal of Pharmaceutical Sciences
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Csöllei, Jozef Muselík, Jan Malik, Ivan Sedlářová, E. Sichrovska, Ľubica
issn	1816-1820
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.3329/dujps.v12i1.16296
http://localhost/t...ganizacniJednotka	16370

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