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| rdf:type
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| Description
| - Basic esters of ortho-alkoxyphenylcarbamic acid containing 4-(2-fluoro-/4-fluoro-/3-trifluoromethylphenyl)-piperazin-1-yI, 5a-8b, were screened for their in vitro antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus, respectively. Following the minimum inhibitory concentration (MIC) assay, electronic and hydrophobic interactions, induced by suitable substitution at the N-phenylpiperazine ring, have appeared to be more notable factors which positively influenced the efficiency of such compounds against E. coli than the rising of their lipophilicity. Molecules comprising only of single atom of fluorine, 5a-6b, were observed to be more active (MIC=0.39-0.78 mg-mL-1) in the comparison to those with trifluromethyl group (MICs}1.00 mg-mL-1). On the contrary, the lipophilicity increasing of evaluated molecules accompanied by the presence of the substituent at N-phenylpiperazine with electron-withdrawing effect, 8a-8b, has positively reflected in their efficiency against C. albicans with the observed maximum of MIC=0.78 mg-mL-1. However, all tested molecules were against S. aureus (MICs}1.00 mg-mL-1) practically inactive
- Basic esters of ortho-alkoxyphenylcarbamic acid containing 4-(2-fluoro-/4-fluoro-/3-trifluoromethylphenyl)-piperazin-1-yI, 5a-8b, were screened for their in vitro antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus, respectively. Following the minimum inhibitory concentration (MIC) assay, electronic and hydrophobic interactions, induced by suitable substitution at the N-phenylpiperazine ring, have appeared to be more notable factors which positively influenced the efficiency of such compounds against E. coli than the rising of their lipophilicity. Molecules comprising only of single atom of fluorine, 5a-6b, were observed to be more active (MIC=0.39-0.78 mg-mL-1) in the comparison to those with trifluromethyl group (MICs}1.00 mg-mL-1). On the contrary, the lipophilicity increasing of evaluated molecules accompanied by the presence of the substituent at N-phenylpiperazine with electron-withdrawing effect, 8a-8b, has positively reflected in their efficiency against C. albicans with the observed maximum of MIC=0.78 mg-mL-1. However, all tested molecules were against S. aureus (MICs}1.00 mg-mL-1) practically inactive (en)
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| Title
| - Basic ortho-alkoxyphenylcarbamic acid esters containing variously substituted n-phenyl piperazine fragment and their antimicrobial activity
- Basic ortho-alkoxyphenylcarbamic acid esters containing variously substituted n-phenyl piperazine fragment and their antimicrobial activity (en)
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| skos:prefLabel
| - Basic ortho-alkoxyphenylcarbamic acid esters containing variously substituted n-phenyl piperazine fragment and their antimicrobial activity
- Basic ortho-alkoxyphenylcarbamic acid esters containing variously substituted n-phenyl piperazine fragment and their antimicrobial activity (en)
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| skos:notation
| - RIV/62157124:16370/13:43872369!RIV14-MSM-16370___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16370/13:43872369
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Substituted N-phenylpiperazine; Phenylcarbamates; Escherichia colr; Candida albicans (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Fresenius Environmental Bulletin
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Csöllei, Jozef
- Malík, Ivan
- Sedlárová, Eva
- Bukovský, Marián
- Sichrovská, Ľubica
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| http://linked.open...ain/vavai/riv/wos
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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