About: Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Three cationic acrylic polymers, i. e. Eudragit RL, Eudragit RS and Eudragit E 100 were evaluated for the purpose of microparticles preparation by the solvent evaporation method. Practically insoluble drug mirtazapine and freely soluble drug tramadol hydrochloride were selected for encapsulation as extreme limits of drug solubility. Prepared microspheres were analyzed by optical microscopy, drug content analysis and dissolution test. It was observed that Eudragit RL did not provide microparticles while Eudragit RS and Eudragit E 100 gave spherical microparticles. Samples prepared with mirtazapine showed sustained drug release whereas tramadol hydrochloride samples released the drug in a pattern similar to immediate release profile. Eudragit RS was found to be superior to Eudragit E 100 in its encapsulation efficiency, drug loading and smaller mean size of microparticles. Three cationic acrylic polymers, i. e. Eudragit RL, Eudragit RS and Eudragit E 100 were evaluated for the purpose of microparticles preparation by the solvent evaporation method. Practically insoluble drug mirtazapine and freely soluble drug tramadol hydrochloride were selected for encapsulation as extreme limits of drug solubility. Prepared microspheres were analyzed by optical microscopy, drug content analysis and dissolution test. It was observed that Eudragit RL did not provide microparticles while Eudragit RS and Eudragit E 100 gave spherical microparticles. Samples prepared with mirtazapine showed sustained drug release whereas tramadol hydrochloride samples released the drug in a pattern similar to immediate release profile. Eudragit RS was found to be superior to Eudragit E 100 in its encapsulation efficiency, drug loading and smaller mean size of microparticles. (en)
Title	Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method (en)
skos:prefLabel	Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method Cationic Eudragit Polymers as Excipients for Microparticles Prepared by Solvent Evaporation Method (en)
skos:notation	RIV/62157124:16370/13:43872056!RIV14-MSM-16370___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Vysloužil, Jakub Dvořáčková, Kateřina Bajerová, Martina Vetchý, David
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	64422
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/13:43872056
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	microparticles, solvent evaporation, sustained drug release, Eudragit? (en)
http://linked.open.../riv/klicoveSlovo	microparticles Eudragit? sustained drug release solvent evaporation
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[49B95B84B5CD]
http://linked.open...i/riv/nazevZdroje	Česká a slovenská farmacie
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	62
http://linked.open...iv/tvurceVysledku	Dvořáčková, Kateřina Vetchý, David Kejdušová, Martina Bavoľárová, Jana Vysloužil, Jakub
issn	1210-7816
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	16370

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