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  • Inflammation is a very important part of innate immunity and is regulated in many steps. One such regulating step is the cytokine network, where tumor necrosis factor a (TNF-a) plays one of the most important roles. A PubMed and Web of Science databases search was performed for studies providing evidences on the role of TNF-a in inflammation, apoptosis, and cancer. This review concisely summarizes the role of this pro-inflammatory cytokine during inflammation. It is focused mainly on TNF-a intracellular signaling and its influence on the typical inflammatory features in the organism. Being one of the most important pro-inflammatory cytokines, TNF-a participates in vasodilatation and edema formation, and leukocyte adhesion to epithelium through expression of adhesion molecules; it regulates blood coagulation, contributes to oxidative stress in sites of inflammation, and indirectly induces fever. The connection between TNF-a and cancer is mentioned as well.
  • Inflammation is a very important part of innate immunity and is regulated in many steps. One such regulating step is the cytokine network, where tumor necrosis factor a (TNF-a) plays one of the most important roles. A PubMed and Web of Science databases search was performed for studies providing evidences on the role of TNF-a in inflammation, apoptosis, and cancer. This review concisely summarizes the role of this pro-inflammatory cytokine during inflammation. It is focused mainly on TNF-a intracellular signaling and its influence on the typical inflammatory features in the organism. Being one of the most important pro-inflammatory cytokines, TNF-a participates in vasodilatation and edema formation, and leukocyte adhesion to epithelium through expression of adhesion molecules; it regulates blood coagulation, contributes to oxidative stress in sites of inflammation, and indirectly induces fever. The connection between TNF-a and cancer is mentioned as well. (en)
Title
  • TNF-alpha signalling and inflammation: interactions between old acquaintances
  • TNF-alpha signalling and inflammation: interactions between old acquaintances (en)
skos:prefLabel
  • TNF-alpha signalling and inflammation: interactions between old acquaintances
  • TNF-alpha signalling and inflammation: interactions between old acquaintances (en)
skos:notation
  • RIV/62157124:16370/13:43871818!RIV14-MSM-16370___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
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  • 111187
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  • RIV/62157124:16370/13:43871818
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  • Cancer; Apoptosis; Inflammation; TNFR; TNF-alpha (en)
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http://linked.open...odStatuVydavatele
  • CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV
  • [9DCF8C6F6009]
http://linked.open...i/riv/nazevZdroje
  • Inflammation research
http://linked.open...in/vavai/riv/obor
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  • 62
http://linked.open...iv/tvurceVysledku
  • Hošek, Jan
  • Zelová, Hana
http://linked.open...ain/vavai/riv/wos
  • 000320377500002
issn
  • 1023-3830
number of pages
http://bibframe.org/vocab/doi
  • 10.1007/s00011-013-0633-0
http://localhost/t...ganizacniJednotka
  • 16370
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