About: Use of Metabolomics for Monitoring Metabolic Responses Caused by Drug Administration 2. Application of Metabolomics in the Study of Metabolic Changes Induced by Drugs

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The aim of the paper is to present metabolomics as an effective tool for the study of responses of humans to drug treatment or animal models to drug administration. Generally, metabolomics can be used for monitoring disease status and drug efficacy, drug metabolism, toxicity and drug-drug interactions. Attention is focused on different classes of drugs, and metabolite alterations caused by drug administration are analysed. Individual drugs are classified according to ATC groups. The selected drugs and pharmacotherapeutic groups were chosen according to their market share or potential. Antipsychotics, anti-inflammatory and antipyretic drugs, antihyperlipidemic agents, antiplatelet/anticoagulant drugs, antimicrobial chemotherapeutics, antineoplastic agents, immunosuppressants and contraceptives are discussed. In addition, the perspectives of the use of metabolomics for future drug discovery are outlined. The aim of the paper is to present metabolomics as an effective tool for the study of responses of humans to drug treatment or animal models to drug administration. Generally, metabolomics can be used for monitoring disease status and drug efficacy, drug metabolism, toxicity and drug-drug interactions. Attention is focused on different classes of drugs, and metabolite alterations caused by drug administration are analysed. Individual drugs are classified according to ATC groups. The selected drugs and pharmacotherapeutic groups were chosen according to their market share or potential. Antipsychotics, anti-inflammatory and antipyretic drugs, antihyperlipidemic agents, antiplatelet/anticoagulant drugs, antimicrobial chemotherapeutics, antineoplastic agents, immunosuppressants and contraceptives are discussed. In addition, the perspectives of the use of metabolomics for future drug discovery are outlined. (en)
Title	Use of Metabolomics for Monitoring Metabolic Responses Caused by Drug Administration 2. Application of Metabolomics in the Study of Metabolic Changes Induced by Drugs Use of Metabolomics for Monitoring Metabolic Responses Caused by Drug Administration 2. Application of Metabolomics in the Study of Metabolic Changes Induced by Drugs (en)
skos:prefLabel	Use of Metabolomics for Monitoring Metabolic Responses Caused by Drug Administration 2. Application of Metabolomics in the Study of Metabolic Changes Induced by Drugs Use of Metabolomics for Monitoring Metabolic Responses Caused by Drug Administration 2. Application of Metabolomics in the Study of Metabolic Changes Induced by Drugs (en)
skos:notation	RIV/62157124:16370/12:43871553!RIV13-MSM-16370___
http://linked.open...avai/riv/aktivita	V
http://linked.open...avai/riv/aktivity	V
http://linked.open...iv/cisloPeriodika	1-2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Jampílek, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	176383
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/12:43871553
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	pharmacotherapeutic groups; drugs; metabolite; metabolic profiling; metabolomics (en)
http://linked.open.../riv/klicoveSlovo	metabolic profiling drugs metabolite pharmacotherapeutic groups metabolomics - metabolic profiling - metabolic %22fingerprint%22- medicinal plants
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[83EEC9BB4770]
http://linked.open...i/riv/nazevZdroje	International Bulletion of Pharmaceutical Sciences
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	1
http://linked.open...iv/tvurceVysledku	Jampílek, Josef Ostrovský, Ivan Kráľová, Katarína
issn	1805-4161
number of pages	13 (xsd:int)
http://localhost/t...ganizacniJednotka	16370

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