About: Mammalian metallothioneins: properties and functions

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs. Metallothioneins (MT) are a family of ubiquitous proteins, whose role is still discussed in numerous papers, but their affinity to some metal ions is undisputable. These cysteine-rich proteins are connected with antioxidant activity and protective effects on biomolecules against free radicals, especially reactive oxygen species. In this review, the connection between zinc(II) ions, reactive oxygen species, heavy metal ions and metallothioneins is demonstrated with respect to effect of these proteins on cell proliferation and a possible negative role in resistance to heavy metal-based and non-heavy metal-based drugs. (en)
Title	Mammalian metallothioneins: properties and functions Mammalian metallothioneins: properties and functions (en)
skos:prefLabel	Mammalian metallothioneins: properties and functions Mammalian metallothioneins: properties and functions (en)
skos:notation	RIV/62157124:16370/12:43871287!RIV13-MSM-16370___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(GAP102/11/1068), P(GAP301/10/0356), P(KAN208130801)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Babula, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	147944
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/12:43871287
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mammals; cell proliferation; cysteine-rich proteins; antioxidant activity; metallothioneins (en)
http://linked.open.../riv/klicoveSlovo	antioxidant activity cell proliferation cysteine-rich proteins metallothioneins mammals
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C40313337C20]
http://linked.open...i/riv/nazevZdroje	Metallomics
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	10 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED) Nano-Electro-Bio-Tools for Biochemical and Molecularly-Biological Studies of Eukaryotic Cells (NanoBioTECell)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	4
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Babula, Petr Hubálek, Jaromír Kizek, René Masařík, Michal Provazník, Ivo Stiborová, Marie Trnková, Libuše Eckschlager, Tomas Skutková, Helena
http://linked.open...ain/vavai/riv/wos	000306854900002
issn	1756-5901
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c2mt20081c
http://localhost/t...ganizacniJednotka	16370

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