About: Synthesis and Characterization of (Z)-5-Arylmethylidenerhodanines with Photosynthesis-Inhibiting Properties

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	A series of rhodanine derivatives was prepared. The synthetic approach, analytical and spectroscopic data of all synthesized compounds are presented. Lipophilicity of all the discussed rhodanine derivatives was analyzed using the RP-HPLC method. The compounds were tested for their ability to inhibit photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts and reduce chlorophyll content in freshwater alga Chlorella vulgaris. Structure-activity relationships between the chemical structure, physical properties and biological activities of the evaluated compounds are discussed. For majority of the tested compounds the lipophilicity of the compound and not electronic properties of the R1 substituent were decisive for PET-inhibiting activity. The most potent PET inhibitor was (5Z)-5-(4-bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (IC50 = 3.0 mýmol/L) and the highest antialgal activity was exhibited by (5Z)-5-(4-chlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (IC50 = 1.3 mýmol/L). A series of rhodanine derivatives was prepared. The synthetic approach, analytical and spectroscopic data of all synthesized compounds are presented. Lipophilicity of all the discussed rhodanine derivatives was analyzed using the RP-HPLC method. The compounds were tested for their ability to inhibit photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts and reduce chlorophyll content in freshwater alga Chlorella vulgaris. Structure-activity relationships between the chemical structure, physical properties and biological activities of the evaluated compounds are discussed. For majority of the tested compounds the lipophilicity of the compound and not electronic properties of the R1 substituent were decisive for PET-inhibiting activity. The most potent PET inhibitor was (5Z)-5-(4-bromobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (IC50 = 3.0 mýmol/L) and the highest antialgal activity was exhibited by (5Z)-5-(4-chlorobenzylidene)-2-thioxo-1,3-thiazolidin-4-one (IC50 = 1.3 mýmol/L). (en)
Title	Synthesis and Characterization of (Z)-5-Arylmethylidenerhodanines with Photosynthesis-Inhibiting Properties Synthesis and Characterization of (Z)-5-Arylmethylidenerhodanines with Photosynthesis-Inhibiting Properties (en)
skos:prefLabel	Synthesis and Characterization of (Z)-5-Arylmethylidenerhodanines with Photosynthesis-Inhibiting Properties Synthesis and Characterization of (Z)-5-Arylmethylidenerhodanines with Photosynthesis-Inhibiting Properties (en)
skos:notation	RIV/62157124:16370/11:43870795!RIV12-MSM-16370___
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(MSM0021620822)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Jampílek, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	233865
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/11:43870795
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	structure-activity relationships; Chlorella vulgaris; spinach chloroplasts; photosynthesis inhibition; lipophilicity; synthesis; rhodanine derivatives (en)
http://linked.open.../riv/klicoveSlovo	structure-activity relationships spinach chloroplasts Chlorella vulgaris photosynthesis inhibition rhodanine derivatives lipophilicity synthesis
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[9C3F8F36CAC2]
http://linked.open...i/riv/nazevZdroje	Molecules
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Doležel, Jan Jampílek, Josef Kuneš, Jiří Kráľová, Katarína Opletalová, Veronika Peško, Matúš
http://linked.open...ain/vavai/riv/wos	000292032700068
http://linked.open...n/vavai/riv/zamer	Research of new drug structures
issn	1420-3049
number of pages	21 (xsd:int)
http://bibframe.org/vocab/doi	10.3390/molecules16065207
http://localhost/t...ganizacniJednotka	16370

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