About: Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells

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About: Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The cytotoxicity and in vitro effects of six variously modified types of cellulose (OC - oxidized cellulose, NaOC - oxidized cellulose sodium salt, DAC - dialdehyde cellulose, CMC - carboxymethyl cellulose, MFC - microfibrilated cellulose, and MCC - microcrystalline cellulose) on the inflammatory response in macrophage-like THP-1 cells were examined, with special focus on their ability to influence gene expression and the production of TNF-alpha. The study provides evidence that DAC exerts a marked effect on the induction of TNF-alpha gene expression and its subsequent production in human macrophages. Thus, the use of DAC for anti-hemorrhagic or wound-healing therapy should be considered carefully with regard to its pro-inflammatory activity. On the contrary, MCC showed significant anti-inflammatory effects in the LPS-induced conditions, which might be beneficial for the treatment of non-healing chronic wounds, e.g., diabetic or venous ulcers. The cytotoxicity and in vitro effects of six variously modified types of cellulose (OC - oxidized cellulose, NaOC - oxidized cellulose sodium salt, DAC - dialdehyde cellulose, CMC - carboxymethyl cellulose, MFC - microfibrilated cellulose, and MCC - microcrystalline cellulose) on the inflammatory response in macrophage-like THP-1 cells were examined, with special focus on their ability to influence gene expression and the production of TNF-alpha. The study provides evidence that DAC exerts a marked effect on the induction of TNF-alpha gene expression and its subsequent production in human macrophages. Thus, the use of DAC for anti-hemorrhagic or wound-healing therapy should be considered carefully with regard to its pro-inflammatory activity. On the contrary, MCC showed significant anti-inflammatory effects in the LPS-induced conditions, which might be beneficial for the treatment of non-healing chronic wounds, e.g., diabetic or venous ulcers. (en)
Title	Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells (en)
skos:prefLabel	Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells Cytotoxicity and effects on inflammatory response of modified types of cellulose in macrophage-like THP-1 cells (en)
skos:notation	RIV/62157124:16370/11:43870661!RIV12-MSM-16370___
http://linked.open...avai/riv/aktivita	I P S
http://linked.open...avai/riv/aktivity	I, P(2A-1TP1/073), S
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kollár, Peter Třetinová, Dominika Závalová, Veronika Hošek, Jan Suchý, Pavel Karpíšek, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	192640
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/11:43870661
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	THP-1 cells; Macrophages; Tumor necrosis factor; Inflammation; Cellulose (en)
http://linked.open.../riv/klicoveSlovo	Cellulose Macrophages THP-1 cells Tumor necrosis factor Inflammation
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[6B925F365175]
http://linked.open...i/riv/nazevZdroje	INTERNATIONAL IMMUNOPHARMACOLOGY
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	*New pharmaceutical products based on polysaccharides
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	11
http://linked.open...iv/tvurceVysledku	Hošek, Jan Kollár, Peter Suchý, Pavel Havelka, Pavel Karpíšek, Michal Sopuch, Tomáš Třetinová, Dominika Závalová, Veronika
http://linked.open...ain/vavai/riv/wos	000293723400014
issn	1567-5769
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.intimp.2011.02.016
http://localhost/t...ganizacniJednotka	16370

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