About: Hepatoprotective and TNF-alfa inhibitory activity of Zosima absinthifolia extracts and coumarins     Goto   Sponge   NotDistinct   Permalink

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  • Zosima absinthifolia (ZA) extracts and the coumarins (+)-columbianadin and (-)-deltoin were evaluated for their potential hepatoprotective and antiinflamatory effects in a CCl(4)-induced hepatotoxicity assay in rats and by the inhibition of TNF-alpha production on LPS-stimulated THP-1 macrophages, respectively. Both the ZA extracts and the coumarins showed hepatoprotective activity confirmed by monitoring the ALT/AST levels and by histopathological examination. The antiinflamatory activity, proved by the inhibition of TNF-alpha production, was found to be higher for the n-hexane root extract than for coumarins, suggesting synergic potential of the extract. The concentration of (-)-deltoin and (+)-columbianadin in extracts was determined by HPLC analysis.
  • Zosima absinthifolia (ZA) extracts and the coumarins (+)-columbianadin and (-)-deltoin were evaluated for their potential hepatoprotective and antiinflamatory effects in a CCl(4)-induced hepatotoxicity assay in rats and by the inhibition of TNF-alpha production on LPS-stimulated THP-1 macrophages, respectively. Both the ZA extracts and the coumarins showed hepatoprotective activity confirmed by monitoring the ALT/AST levels and by histopathological examination. The antiinflamatory activity, proved by the inhibition of TNF-alpha production, was found to be higher for the n-hexane root extract than for coumarins, suggesting synergic potential of the extract. The concentration of (-)-deltoin and (+)-columbianadin in extracts was determined by HPLC analysis. (en)
Title
  • Hepatoprotective and TNF-alfa inhibitory activity of Zosima absinthifolia extracts and coumarins
  • Hepatoprotective and TNF-alfa inhibitory activity of Zosima absinthifolia extracts and coumarins (en)
skos:prefLabel
  • Hepatoprotective and TNF-alfa inhibitory activity of Zosima absinthifolia extracts and coumarins
  • Hepatoprotective and TNF-alfa inhibitory activity of Zosima absinthifolia extracts and coumarins (en)
skos:notation
  • RIV/62157124:16370/11:43870281!RIV12-MSM-16370___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 201904
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16370/11:43870281
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • hepatopretective activity; furanocoumarin; deltoin; columbianadin (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [2AD3AFE781F1]
http://linked.open...i/riv/nazevZdroje
  • Fitoterapia
http://linked.open...in/vavai/riv/obor
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 82
http://linked.open...iv/tvurceVysledku
  • Hošek, Jan
  • Šmejkal, Karel
  • Bahadir, Ozlem
  • Citoglu, Gulcin
  • Dall'Acqua, Stefano
  • Ozbek, Hanefi
http://linked.open...ain/vavai/riv/wos
  • 000288354700025
issn
  • 0367-326X
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.fitote.2010.12.007
http://localhost/t...ganizacniJednotka
  • 16370
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