About: Effect of solvent on cytotoxicity and bioavailability of fatty acids.

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About: Effect of solvent on cytotoxicity and bioavailability of fatty acids. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Fatty acids (FAs) represent an important part of cell membranes and a source of energy. However, their abundance is linked with several diseases such as type 2 diabetes mellitus, and for this reason they are studied intensively. In this article we compare the two main methods of dissolving FAs for work in vitro, (i) dissolution in dimethylsulfoxide (DMSO) and (ii) conjugation with bovine serum albumin (BSA), and describe the effects of the solvent on cytotoxicity (determination of viability) and bioavailability (as shown by the impact on the gene expression of TNF-alpha). We have found that conjugation with BSA is significantly less cytotoxic than dissolution in DMSO and also yields greater bioavailability. Fatty acids (FAs) represent an important part of cell membranes and a source of energy. However, their abundance is linked with several diseases such as type 2 diabetes mellitus, and for this reason they are studied intensively. In this article we compare the two main methods of dissolving FAs for work in vitro, (i) dissolution in dimethylsulfoxide (DMSO) and (ii) conjugation with bovine serum albumin (BSA), and describe the effects of the solvent on cytotoxicity (determination of viability) and bioavailability (as shown by the impact on the gene expression of TNF-alpha). We have found that conjugation with BSA is significantly less cytotoxic than dissolution in DMSO and also yields greater bioavailability. (en)
Title	Effect of solvent on cytotoxicity and bioavailability of fatty acids. Effect of solvent on cytotoxicity and bioavailability of fatty acids. (en)
skos:prefLabel	Effect of solvent on cytotoxicity and bioavailability of fatty acids. Effect of solvent on cytotoxicity and bioavailability of fatty acids. (en)
skos:notation	RIV/62157124:16370/10:00002637!RIV11-MSM-16370___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kollár, Peter Závalová, Veronika Hošek, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	256168
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/10:00002637
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cell culture; inflammation; macrophages; myristic acid; RT-qPCR (en)
http://linked.open.../riv/klicoveSlovo	myristic acid inflammation macrophages RT-qPCR Cell culture
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[7763E473C492]
http://linked.open...i/riv/nazevZdroje	Immunopharmacology and Immunotoxicology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Hošek, Jan Kollár, Peter Závalová, Veronika
http://linked.open...ain/vavai/riv/wos	000281917300017
issn	0892-3973
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	16370

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