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  • The objective of this article was the formulation of buccal mucoadhesive tablets, based on oxidized cellulose (OC), in this term new pharmaceutical excipient, and evaluation of OC influence on physico-chemical properties of prepared tablets and their dissolution profiles. Besides usual excipients and mucoadhesive polymers, formulations contained 5 mg of model drug - cetylpyridinium chloride (CPC). The aim of this experiment was to ensure 8 hours prolonged release of CPC and its salivary concentration higher than its MIC (5 ?g/ml), without the necessity of residual tablet fragments elimination from oral cavity.
  • The objective of this article was the formulation of buccal mucoadhesive tablets, based on oxidized cellulose (OC), in this term new pharmaceutical excipient, and evaluation of OC influence on physico-chemical properties of prepared tablets and their dissolution profiles. Besides usual excipients and mucoadhesive polymers, formulations contained 5 mg of model drug - cetylpyridinium chloride (CPC). The aim of this experiment was to ensure 8 hours prolonged release of CPC and its salivary concentration higher than its MIC (5 ?g/ml), without the necessity of residual tablet fragments elimination from oral cavity. (en)
Title
  • Oxycellulose as mucoadhesive polymer in buccal tablets
  • Oxycellulose as mucoadhesive polymer in buccal tablets (en)
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  • Oxycellulose as mucoadhesive polymer in buccal tablets
  • Oxycellulose as mucoadhesive polymer in buccal tablets (en)
skos:notation
  • RIV/62157124:16370/10:00002628!RIV11-MSM-16370___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(2A-1TP1/073), S
http://linked.open...iv/cisloPeriodika
  • 9
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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  • 277887
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16370/10:00002628
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Oxycellulose sodium; prolonged drug release; buccal mucoadhesive tablets; cetylpyridinium chloride; in vitro tablet characterization (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [93B966F35B20]
http://linked.open...i/riv/nazevZdroje
  • Drug Development and Industrial Pharmacy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
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http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 36
http://linked.open...iv/tvurceVysledku
  • Bajerová, Martina
  • Gajdziok, Jan
  • Rabišková, Miloslava
  • Chalupová, Zuzana
http://linked.open...ain/vavai/riv/wos
  • 000282143700012
issn
  • 0363-9045
number of pages
http://localhost/t...ganizacniJednotka
  • 16370
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