About: Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The purpose of this experimental work was the development of hydrophilic - lipophilic matrix tablets for controlled release of slightly soluble drug represented here by diclofenac sodium. Drug dissolution profile optimization provided by soluble filler was studied. Matrix tablets were based on cetyl alcohol as the lipophilic carrier, povidone as the gel forming agent, and common soluble filler, i.e. lactose or sucrose of different particle size. Physical properties of tablets prepared by melt granulation and drug release in a phosphate buffer of pH 6.8 were evaluated. In vitro studies showed that used the filler type, filler to povidone ratio and sucrose particle size influenced the drug release rate. Diclofenac sodium dissolution profile could be changed within a wide range from about 50 % per 24 hours to almost 100 % in 10 hours. The release constant values confirmed that diclofenac sodium was released from matrices by the diffusion and anomalous transport. The influence of sucrose particle size on The purpose of this experimental work was the development of hydrophilic - lipophilic matrix tablets for controlled release of slightly soluble drug represented here by diclofenac sodium. Drug dissolution profile optimization provided by soluble filler was studied. Matrix tablets were based on cetyl alcohol as the lipophilic carrier, povidone as the gel forming agent, and common soluble filler, i.e. lactose or sucrose of different particle size. Physical properties of tablets prepared by melt granulation and drug release in a phosphate buffer of pH 6.8 were evaluated. In vitro studies showed that used the filler type, filler to povidone ratio and sucrose particle size influenced the drug release rate. Diclofenac sodium dissolution profile could be changed within a wide range from about 50 % per 24 hours to almost 100 % in 10 hours. The release constant values confirmed that diclofenac sodium was released from matrices by the diffusion and anomalous transport. The influence of sucrose particle size on (en)
Title	Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets (en)
skos:prefLabel	Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets Soluble filler as the dissolution profile modulator for slightly soluble drugs in matrix tablets (en)
skos:notation	RIV/62157124:16370/09:00002097!RIV10-MSM-16370___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Krejčová, Kateřina Dvořáčková, Kateřina Muselík, Jan Rabišková, Miloslava Masteiková, Ruta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	342288
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/09:00002097
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	matrix tablets; diclofenac sodium; fillers; particle size; drug release; release mechanism (en)
http://linked.open.../riv/klicoveSlovo	particle size release mechanism diclofenac sodium matrix tablets fillers drug release
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[207C83B17807]
http://linked.open...i/riv/nazevZdroje	Drug Development and Industrial Pharmacy
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Dvořáčková, Kateřina Muselík, Jan Rabišková, Miloslava Masteiková, Ruta Krejčová, Kateřina
http://linked.open...ain/vavai/riv/wos	000268879400005
issn	0363-9045
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	16370

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