About: RP-HPLC Determination of Drug Lipophilicity in Series of Quinoline Derivatives     Goto   Sponge   NotDistinct   Permalink

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  • In the present paper we describe results on the synthesis and lipophilicity determination of a series of biologically active compounds based on their heterocyclic structure. For synthesis of styrylquinoline-based compounds we applied microwave irradiation and solid phase techniques. The correlation between RP-HPLC retention parameter log k (the logarithm of retention factor k) and log P data calculated in various ways is discussed, as well as, the relationships between the lipophilicity and the chemical structure of the studied compounds.
  • In the present paper we describe results on the synthesis and lipophilicity determination of a series of biologically active compounds based on their heterocyclic structure. For synthesis of styrylquinoline-based compounds we applied microwave irradiation and solid phase techniques. The correlation between RP-HPLC retention parameter log k (the logarithm of retention factor k) and log P data calculated in various ways is discussed, as well as, the relationships between the lipophilicity and the chemical structure of the studied compounds. (en)
Title
  • RP-HPLC Determination of Drug Lipophilicity in Series of Quinoline Derivatives
  • RP-HPLC Determination of Drug Lipophilicity in Series of Quinoline Derivatives (en)
skos:prefLabel
  • RP-HPLC Determination of Drug Lipophilicity in Series of Quinoline Derivatives
  • RP-HPLC Determination of Drug Lipophilicity in Series of Quinoline Derivatives (en)
skos:notation
  • RIV/62157124:16370/09:00002075!RIV10-MSM-16370___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
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  • 3
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http://linked.open...aciTvurceVysledku
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  • 340054
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16370/09:00002075
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  • Lipophilicity; RP-HPLC; Microwave synthesis; Quinoline derivatives (en)
http://linked.open.../riv/klicoveSlovo
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  • PL - Polská republika
http://linked.open...ontrolniKodProRIV
  • [571CB58D2E6E]
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  • Central European Journal of Chemistry
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  • 7
http://linked.open...iv/tvurceVysledku
  • Dohnal, Jiří
  • Jampílek, Josef
  • Polański, Jarosław
  • Musioł, Robert
  • Finster, Jacek
  • Podeszwa, Barbara
  • Tabak, Dominik
http://linked.open...ain/vavai/riv/wos
  • 000267239200046
issn
  • 1895-1066
number of pages
http://localhost/t...ganizacniJednotka
  • 16370
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