About: Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Flavonoids are one of the largest classes of plant secondary metabolites and are known to possess a number of significant biological activities for human health. In this study, we examined in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of four flavonoid derivatives quercetin, rutin, kaempferol 3-O-β-d-galactoside and macluraxanthone. The in vitro results showed that quercetin and macluraxanthone displayed a concentration-dependant inhibition of AChE and BChE. Macluraxanthone showed to be the most potent and specific inhibitor of both the enzymes having the IC50 values of 8.47 and 29.8 μM, respectively. The enzyme kinetic studies revealed that quercetin inhibited both the enzymes in competitive manner, whereas the mode of inhibition of macluraxanthone was non-competitive against AChE and competitive against BChE. The inhibitory profiles of the compounds have been compared with standard AChE inhibitor galanthamine. To get insight of the intermolecul Flavonoids are one of the largest classes of plant secondary metabolites and are known to possess a number of significant biological activities for human health. In this study, we examined in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of four flavonoid derivatives quercetin, rutin, kaempferol 3-O-β-d-galactoside and macluraxanthone. The in vitro results showed that quercetin and macluraxanthone displayed a concentration-dependant inhibition of AChE and BChE. Macluraxanthone showed to be the most potent and specific inhibitor of both the enzymes having the IC50 values of 8.47 and 29.8 μM, respectively. The enzyme kinetic studies revealed that quercetin inhibited both the enzymes in competitive manner, whereas the mode of inhibition of macluraxanthone was non-competitive against AChE and competitive against BChE. The inhibitory profiles of the compounds have been compared with standard AChE inhibitor galanthamine. To get insight of the intermolecul (en)
Title	Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies (en)
skos:prefLabel	Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies (en)
skos:notation	RIV/62157124:16370/09:00002069!RIV10-MSM-16370___
http://linked.open...avai/riv/aktivita	S
http://linked.open...avai/riv/aktivity	S
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Šmejkal, Karel Dvorská, Margita
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	306993
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/09:00002069
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Alzheimer's disease; Acetylcholinesterase; Butyrylcholinesterase; Flavonoids; Xanthone; Molecular docking Alzheimer's disease; Acetylcholinesterase; Butyrylcholinesterase; Flavonoids; Xanthone; Molecular docking (en)
http://linked.open.../riv/klicoveSlovo	Molecular docking Acetylcholinesterase Alzheimer's disease Flavonoids Butyrylcholinesterase Molecular docking Alzheimer's disease Xanthone
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[A0B0C7D8C203]
http://linked.open...i/riv/nazevZdroje	Chemico-biological interactions
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	181
http://linked.open...iv/tvurceVysledku	Šmejkal, Karel Šlapetová, Tereza Dvorská, Margita Kartal, Murat Khan, Mahmud Orhan, Ilkay Sener, Bilge Senol, Sezer
http://linked.open...ain/vavai/riv/wos	000271043800014
issn	0009-2797
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	16370

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