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  • The paper is devoted to synthesis and study of physicochemical properties of some aryloxyaminopropanol derivatives, the compounds of 2-hydroxy-3-[4-(2-metoxyphenyl)- -piperazin-1-yl]-propyl-4-[(alkoxycarbonyl)amino]benzoates, their salts with hydrochloric acid, with one to four carbon atoms in the alkoxy group of carbamoyl group. Their structure was confirmed by elemental analysis, IR, UV and mass spectra. The melting point, solubility, surface activity, dissociation constant and some lipophilicity parameters, i.e. partition coefficient P, RM values from reversed-phase thin-layer chromatography and retention factor k obtained from HPLC of studied substances were determined.
  • The paper is devoted to synthesis and study of physicochemical properties of some aryloxyaminopropanol derivatives, the compounds of 2-hydroxy-3-[4-(2-metoxyphenyl)- -piperazin-1-yl]-propyl-4-[(alkoxycarbonyl)amino]benzoates, their salts with hydrochloric acid, with one to four carbon atoms in the alkoxy group of carbamoyl group. Their structure was confirmed by elemental analysis, IR, UV and mass spectra. The melting point, solubility, surface activity, dissociation constant and some lipophilicity parameters, i.e. partition coefficient P, RM values from reversed-phase thin-layer chromatography and retention factor k obtained from HPLC of studied substances were determined. (en)
  • Syntéza a studium fyzikálně-chemických vlastností derivátoů aryloxyaminopropanolu, 2-hydroxy-3-[4-(2-methoxyfenyl)-piperazin-1-yl]-propyl-4-[(alkoxykarbonyl)amino]-benzoátů,jejich solí s kyselinou chlorovodíkovou, s jedním až čtyřmi atómy uhlíku v alkoxyskupině karbamoylu. Struktura sloučenin byla potvrzena elementární analýzou, IČ, UV a hmotnostními spektry. Byla stanovena teplota tání, rozpustnost, povrchová aktivita, disociační konstanta a rovněž parametry lipofility, t.j. rozdelovací koeficient, hodnoty RM z reverzní chromatografie na tenké vrstvě a retenční faktor k pomocí vysokoúčinné kvapalinové chromatografie. (cs)
Title
  • Synthesis and physicochemical properties of novel potential ultrashort-acting beta-adrenergic blockers
  • Synthesis and physicochemical properties of novel potential ultrashort-acting beta-adrenergic blockers (en)
  • Syntéza a fyzikálně-chemické vlastnosti nových potenciálních ultrakrátce působících beta-adrenergních blokátorů (cs)
skos:prefLabel
  • Synthesis and physicochemical properties of novel potential ultrashort-acting beta-adrenergic blockers
  • Synthesis and physicochemical properties of novel potential ultrashort-acting beta-adrenergic blockers (en)
  • Syntéza a fyzikálně-chemické vlastnosti nových potenciálních ultrakrátce působících beta-adrenergních blokátorů (cs)
skos:notation
  • RIV/62157124:16370/08:00002034!RIV09-MSM-16370___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • N
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 398742
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16370/08:00002034
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http://linked.open.../riv/klicovaSlova
  • ultrashort-acting beta-blockers; synthesis; physicochemical properties (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • SK - Slovenská republika
http://linked.open...ontrolniKodProRIV
  • [3C3795536E75]
http://linked.open...i/riv/nazevZdroje
  • Acta Facultatis Pharmaceuticae Universitatis Comenianae Bratislava
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 55
http://linked.open...iv/tvurceVysledku
  • Csöllei, Jozef
  • Mokrý, Petr
  • Sedlárová, Eva
  • Vančo, Ján
  • Kečkéšová, Simona
  • Vanko, Marián
issn
  • 0301-2298
number of pages
http://localhost/t...ganizacniJednotka
  • 16370
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