About: Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes (cs) Considering the important role of antioxidants in biological systems, the group of copper(II) complexes derived from salicylaldehyde and alpha- or beta-alanine and its thiourea derivative and copper(II) complexes derived from pyruvic acid and beta-alanine were studied. The antiradical activity of the tested compounds was studied by both in vitro and in vivo methods. The chemical methods based on inhibition of INT-formazane or 3-nitrotyrosine formation were used for the evaluation of SOD-mimic and antiperoxynitrite activity, respectively. In the case of in vivo activity evaluation, an alloxan-induced diabetes mellitus model in mice was used, the mechanism of action of alloxan being closely connected with the formation of free radicals selectively damaging the pancreatic beta-cells. Since all the substances studied showed different positive effects, it is obvious that they have not acted only as a source of copper(II) ions but their effect is related to their specific chelate structure. The obtained res Considering the important role of antioxidants in biological systems, the group of copper(II) complexes derived from salicylaldehyde and alpha- or beta-alanine and its thiourea derivative and copper(II) complexes derived from pyruvic acid and beta-alanine were studied. The antiradical activity of the tested compounds was studied by both in vitro and in vivo methods. The chemical methods based on inhibition of INT-formazane or 3-nitrotyrosine formation were used for the evaluation of SOD-mimic and antiperoxynitrite activity, respectively. In the case of in vivo activity evaluation, an alloxan-induced diabetes mellitus model in mice was used, the mechanism of action of alloxan being closely connected with the formation of free radicals selectively damaging the pancreatic beta-cells. Since all the substances studied showed different positive effects, it is obvious that they have not acted only as a source of copper(II) ions but their effect is related to their specific chelate structure. The obtained res (en)
Title	Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes (en) Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes (cs)
skos:prefLabel	Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes (en) Antiradical activity of different copper(II) Schiff base complexes and their effect on alloxan-induced diabetes (cs)
skos:notation	RIV/62157124:16370/04:00000089!RIV/2005/MSM/163705/N
http://linked.open.../vavai/riv/strany	155-161
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 163700003)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2005
http://linked.open...aciTvurceVysledku	Muselík, Jan Vančo, Ján
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Farmaceutická fakulta
http://linked.open...dnocenehoVysledku	554844
http://linked.open...ai/riv/idVysledku	RIV/62157124:16370/04:00000089
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	copper(II) complexes;antiradical activity (en)
http://linked.open.../riv/klicoveSlovo	antiradical activity copper(II) complexes
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C41532535D65]
http://linked.open...i/riv/nazevZdroje	Journal of Trace Elements in Medicine and Biology
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Račanská, Eva Muselík, J. Vančo, J. Valentová, Jindra Švajlenová, Oľga
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20163700003
issn	0946-672X
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	16370

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