About: Reversion to susceptibility of a carbapenem-resistant clinical isolate of Klebsiella pneumoniae producing KPC-3     Goto   Sponge   NotDistinct   Permalink

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  • Objectives: We report the case of a kidney-transplant patient, suffering an intra-abdominal abscess at the surgical site caused by a carbapenem-resistant ST258 Klebsiella pneumoniae clone, producing the KPC-3 carbapenemase. Under tigecycline treatment, the patient developed a sepsis caused by a carbapenem-susceptible ST258 K. pneumoniae strain. Complete DNA sequences of the plasmids carried by the resistant and susceptible strains from this patient were determined. Methods: The complete DNA sequences of plasmids were obtained by applying the 454 Genome Sequencer FLX-PLUS procedure on a library constructed of total plasmid DNA purified from the carbapenem-resistant and-susceptible strains. Results: In the carbapenem-resistant strain, four plasmids encoding 24 resistance genes, including bla(KPC-3), and two putative virulence clusters were detected. In the susceptible strain, large rearrangements occurred in the KPC-carrying plasmid, causing the deletion of the entire Tn4401::bla(KPC-3) transposon, with the consequent reversion of the strain to carbapenem susceptibility. The patient was successfully treated with carbapenems and fully recovered. Conclusions: The description of the plasmid content in these two strains gives interesting insights into the plasticity of KPC-carrying plasmids in K. pneumoniae.
  • Objectives: We report the case of a kidney-transplant patient, suffering an intra-abdominal abscess at the surgical site caused by a carbapenem-resistant ST258 Klebsiella pneumoniae clone, producing the KPC-3 carbapenemase. Under tigecycline treatment, the patient developed a sepsis caused by a carbapenem-susceptible ST258 K. pneumoniae strain. Complete DNA sequences of the plasmids carried by the resistant and susceptible strains from this patient were determined. Methods: The complete DNA sequences of plasmids were obtained by applying the 454 Genome Sequencer FLX-PLUS procedure on a library constructed of total plasmid DNA purified from the carbapenem-resistant and-susceptible strains. Results: In the carbapenem-resistant strain, four plasmids encoding 24 resistance genes, including bla(KPC-3), and two putative virulence clusters were detected. In the susceptible strain, large rearrangements occurred in the KPC-carrying plasmid, causing the deletion of the entire Tn4401::bla(KPC-3) transposon, with the consequent reversion of the strain to carbapenem susceptibility. The patient was successfully treated with carbapenems and fully recovered. Conclusions: The description of the plasmid content in these two strains gives interesting insights into the plasticity of KPC-carrying plasmids in K. pneumoniae. (en)
Title
  • Reversion to susceptibility of a carbapenem-resistant clinical isolate of Klebsiella pneumoniae producing KPC-3
  • Reversion to susceptibility of a carbapenem-resistant clinical isolate of Klebsiella pneumoniae producing KPC-3 (en)
skos:prefLabel
  • Reversion to susceptibility of a carbapenem-resistant clinical isolate of Klebsiella pneumoniae producing KPC-3
  • Reversion to susceptibility of a carbapenem-resistant clinical isolate of Klebsiella pneumoniae producing KPC-3 (en)
skos:notation
  • RIV/62157124:16270/13:43872434!RIV14-MSM-16270___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • N
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  • 11
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http://linked.open...iv/duvernostUdaju
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http://linked.open...dnocenehoVysledku
  • 102785
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16270/13:43872434
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • sequence type 258; plasmids; transplant (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [2E54469AB9F5]
http://linked.open...i/riv/nazevZdroje
  • Journal of Antimicrobial Chemotherapy
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 68
http://linked.open...iv/tvurceVysledku
  • Dolejská, Monika
  • Carattoli, Alessandra
  • Villa, Laura
  • Fortini, Daniela
  • Capone, Alessandro
  • De Paolis, Paolo
  • Petrosillo, Nicola
  • Rodriguez, Irene
  • Taglietti, Fabrizio
http://linked.open...ain/vavai/riv/wos
  • 000326978600012
issn
  • 0305-7453
number of pages
http://bibframe.org/vocab/doi
  • 10.1093/jac/dkt235
http://localhost/t...ganizacniJednotka
  • 16270
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