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| Description
| - Several organs are derived from the ectoderm. Development of these structures is controlled by interplay of proliferation, differentiation and cell death mainly mediated by caspase activation. Caspase-7 together with caspases-3 and -6 belongs to the trio of executive caspases. Despite the primary pro-apoptotic character of these caspases, they have been supposed to play roles in non-apoptotic events. Such non-apoptotic function for caspase-7 was revealed in our laboratory when cleaved caspase-7 was found during differentiation of odontoblasts, ameloblasts, osteoblasts and in other non-apoptotic cells. To find out if such non-apoptotic role of caspase-7 might be linked also to development of other ectoderm-derived organs, mouse hair follicles were investigated. Immunohistochemistry was used to detect cleaved (activated) caspase-7 and correlate its presence with occurrence of apoptosis. To reveal the specific influence of caspase-7 on apoptotic signalling networks, changes of expression of more than 80 apoptosis-related genes were examined by PCR arrays method in caspase-7 knock-out mice. The skin at the embryonic stage 15.5 which is connected with an onset of hair follicle development was evaluated in this study. During development, activated caspase-7 was found in hair follicles. Notably, activated caspase-7 was observed at stages where no apoptosis occurred. In caspase-7 deficient skin, statistically significant increase in expression of several other caspases, particularly casp1, casp12 and casp14 was revealed. Our results indicate a role of caspase-7 in cell differentiation in the skin/hair follicle development and might suggest compensatory caspase mechanisms in the case of caspase-7 deficiency. This work was supported by GACR P502/12/1285
- Several organs are derived from the ectoderm. Development of these structures is controlled by interplay of proliferation, differentiation and cell death mainly mediated by caspase activation. Caspase-7 together with caspases-3 and -6 belongs to the trio of executive caspases. Despite the primary pro-apoptotic character of these caspases, they have been supposed to play roles in non-apoptotic events. Such non-apoptotic function for caspase-7 was revealed in our laboratory when cleaved caspase-7 was found during differentiation of odontoblasts, ameloblasts, osteoblasts and in other non-apoptotic cells. To find out if such non-apoptotic role of caspase-7 might be linked also to development of other ectoderm-derived organs, mouse hair follicles were investigated. Immunohistochemistry was used to detect cleaved (activated) caspase-7 and correlate its presence with occurrence of apoptosis. To reveal the specific influence of caspase-7 on apoptotic signalling networks, changes of expression of more than 80 apoptosis-related genes were examined by PCR arrays method in caspase-7 knock-out mice. The skin at the embryonic stage 15.5 which is connected with an onset of hair follicle development was evaluated in this study. During development, activated caspase-7 was found in hair follicles. Notably, activated caspase-7 was observed at stages where no apoptosis occurred. In caspase-7 deficient skin, statistically significant increase in expression of several other caspases, particularly casp1, casp12 and casp14 was revealed. Our results indicate a role of caspase-7 in cell differentiation in the skin/hair follicle development and might suggest compensatory caspase mechanisms in the case of caspase-7 deficiency. This work was supported by GACR P502/12/1285 (en)
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| Title
| - Caspase-7 in development of ectodermal organs: Apoptosis or differentiation?
- Caspase-7 in development of ectodermal organs: Apoptosis or differentiation? (en)
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| skos:prefLabel
| - Caspase-7 in development of ectodermal organs: Apoptosis or differentiation?
- Caspase-7 in development of ectodermal organs: Apoptosis or differentiation? (en)
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| skos:notation
| - RIV/62157124:16170/14:43873328!RIV15-GA0-16170___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16170/14:43873328
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - development; apoptosis; hair follicle; caspase-7 (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...iv/tvurceVysledku
| - Matalová, Eva
- Veselá, Barbora
- Švandová, Eva
- Berghe, Tom Vanden
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| http://localhost/t...ganizacniJednotka
| |
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