About: Familial narcolepsy in the Lipizzaner horse: a report of three fillies born to the same sire

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Three half sibling Lipizzaner mares with excessive sleepiness were examined for sleepiness, swaying, stumbling, carpal joints buckling and falling down onto the carpal joints. Clinical signs had been present since early foal age in all of them and gradually reduced since the age of two years in cases 1 and 3. Sleepiness was induced by going out from the stable in adulthood. A physostigmine test was performed in all three affected horses and produced positive results in cases 1 and 3. The result of the test in case 2 was unclear due to the almost continuous sleepiness of the foal. Hypocretin-1 concentration in the CSF was established using a standardized radioimmunoassay in case 1 (317.85 pg/ml), case 2 (303.43 pg/ml) and an adult control horse (269.75 pg/ml) and was considered as normal in all horses. The sire of the affected horses has had 19 other registered offspring who did not show clinical signs of sleep disorder and also dams of all three cases produced healthy foals. Based on the demographic and clinical data together with the responses to the physostigmine challenges, the diagnosis of familial equine narcolepsy was made. Three half sibling Lipizzaner mares with excessive sleepiness were examined for sleepiness, swaying, stumbling, carpal joints buckling and falling down onto the carpal joints. Clinical signs had been present since early foal age in all of them and gradually reduced since the age of two years in cases 1 and 3. Sleepiness was induced by going out from the stable in adulthood. A physostigmine test was performed in all three affected horses and produced positive results in cases 1 and 3. The result of the test in case 2 was unclear due to the almost continuous sleepiness of the foal. Hypocretin-1 concentration in the CSF was established using a standardized radioimmunoassay in case 1 (317.85 pg/ml), case 2 (303.43 pg/ml) and an adult control horse (269.75 pg/ml) and was considered as normal in all horses. The sire of the affected horses has had 19 other registered offspring who did not show clinical signs of sleep disorder and also dams of all three cases produced healthy foals. Based on the demographic and clinical data together with the responses to the physostigmine challenges, the diagnosis of familial equine narcolepsy was made. (en)
Title	Familial narcolepsy in the Lipizzaner horse: a report of three fillies born to the same sire Familial narcolepsy in the Lipizzaner horse: a report of three fillies born to the same sire (en)
skos:prefLabel	Familial narcolepsy in the Lipizzaner horse: a report of three fillies born to the same sire Familial narcolepsy in the Lipizzaner horse: a report of three fillies born to the same sire (en)
skos:notation	RIV/62157124:16170/12:43870956!RIV13-MSM-16170___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6215712403)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Jahn, Petr Ludvíková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Fakulta veterinárního lékařství
http://linked.open...dnocenehoVysledku	136141
http://linked.open...ai/riv/idVysledku	RIV/62157124:16170/12:43870956
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	hypocretin; cataplexy; narcolepsy; horse (en)
http://linked.open.../riv/klicoveSlovo	narcolepsy cataplexy horse hypocretin
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[68975BBF4E68]
http://linked.open...i/riv/nazevZdroje	Veterinary quarterly
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Jahn, Petr Ludvíková, Eva Nishino, Seiji Sakai, Noriaki
http://linked.open...ain/vavai/riv/wos	000308251400005
http://linked.open...n/vavai/riv/zamer	Active creation of health, yield and performance of the large animals
issn	0165-2176
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1080/01652176.2012.714089
http://localhost/t...ganizacniJednotka	16170

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