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| Description
| - Práce popisuje tři případy nutriční myodegenerace způsobené deficiencí selenu. Všichni postižení koně vykazovali obtíže s příjmem pevného krmiva i vody. Vyšetření krve odhalilo výraznou elevaci aktivity svalových enzymů a nízkou aktivitu GSH-Px nebo koncentraci selenu v plné krvi u všech případů. Postiženým koním byl aplikován seleničitan sodný. Dva z těchto koní byli utraceni z důvodu neustále progrese onemocnění, jedna klisna se zcela uzdravila. Patomorfologické vyšetření utracených koní odhalilo bilaterálně symetrické oblasti bledé svaloviny na pánevních i hrudních končetinách, bránici, bledou svalovinu jazyka, žvýkacích a mezižeberních svalů a myokardu. Histopatologické vyšetření prokázalo v postižených oblastech degeneraci a nekrózu svalových vláken provázenou lymfocytoplazmocitární infiltrací. Průběh a prognóza je pravděpodobně ovlivněna včasnou diagnózou a terapií onemocnění. (cs)
- Three cases of nutritional myodegeneration caused by selenium deficiency in adult horses are described. The common clinical sign in all horses was difficulty in eating and drinking. Blood biochemistry revealed marked elevation of muscle enzymes and low gluthationperoxidase activity or low selenium concentration in whole blood in all cases. Treatment by natrium selenite and vitamin E was instituted in all horses. Two of them were euthanized because of continuing muscle injury, one patient was cured. Post-mortem examination of the euthanized horses revealed pale muscles that were distributed with bilateral symmetry on hind and thoracic limbs, diaphragm, tongue, masticatory and intercostal muscles and the myocardium. Histopathology revealed areas of degeneration and necrosis. Large groups of regenerating fibres and pronounced lymphoplasmocytic reaction among groups of intact fibres were also present. Clinical outcome of the disease is probably influenced by timely diagnosis and treatment.
- Three cases of nutritional myodegeneration caused by selenium deficiency in adult horses are described. The common clinical sign in all horses was difficulty in eating and drinking. Blood biochemistry revealed marked elevation of muscle enzymes and low gluthationperoxidase activity or low selenium concentration in whole blood in all cases. Treatment by natrium selenite and vitamin E was instituted in all horses. Two of them were euthanized because of continuing muscle injury, one patient was cured. Post-mortem examination of the euthanized horses revealed pale muscles that were distributed with bilateral symmetry on hind and thoracic limbs, diaphragm, tongue, masticatory and intercostal muscles and the myocardium. Histopathology revealed areas of degeneration and necrosis. Large groups of regenerating fibres and pronounced lymphoplasmocytic reaction among groups of intact fibres were also present. Clinical outcome of the disease is probably influenced by timely diagnosis and treatment. (en)
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| Title
| - Nutritional myodegeneration as a cause of dysphagia in adult horses.
- Nutriční myodegenerace jako příčina dysfagie u dospělých koní (cs)
- Nutritional myodegeneration as a cause of dysphagia in adult horses. (en)
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| skos:prefLabel
| - Nutritional myodegeneration as a cause of dysphagia in adult horses.
- Nutriční myodegenerace jako příčina dysfagie u dospělých koní (cs)
- Nutritional myodegeneration as a cause of dysphagia in adult horses. (en)
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| skos:notation
| - RIV/62157124:16170/07:00001474!RIV08-MSM-16170___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16170/07:00001474
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - selenium; α-tocopherol-acetate; vitamin E; myopathy; glutathione peroxidase (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Jahn, Petr
- Lukáš, Zdeněk
- Ludvíková, Eva
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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