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| Description
| - During molar development, apoptosis occurs in a well-characterised pattern suggesting several roles for cell death in odontogenesis. However, molecular mechanisms of dental apoptosis are only poorly understood. In this study, Apaf-1 and caspase-9 knockouts were used to uncover the engagement of these members of the apoptotic machinery during early tooth development, concentrating primarily on their function in the apoptotic elimination of primary enamel knot cells. Molar tooth germ morphology, proliferation and apoptosis were investigated on frontal histological sections of murine heads at embryonic days (ED) 15.5, the stage when the primary enamel knot is eliminated apoptotically. In molar tooth germs of both knockouts, no apoptosis was observed according to morphological (haematoxylin-eosin) as well as biochemical criteria (TUNEL). Morphology of the mutant tooth germs, however, was not changed. Additionally, knockout mice showed no changes in proliferation compared to wild type mice. According to ou
- During molar development, apoptosis occurs in a well-characterised pattern suggesting several roles for cell death in odontogenesis. However, molecular mechanisms of dental apoptosis are only poorly understood. In this study, Apaf-1 and caspase-9 knockouts were used to uncover the engagement of these members of the apoptotic machinery during early tooth development, concentrating primarily on their function in the apoptotic elimination of primary enamel knot cells. Molar tooth germ morphology, proliferation and apoptosis were investigated on frontal histological sections of murine heads at embryonic days (ED) 15.5, the stage when the primary enamel knot is eliminated apoptotically. In molar tooth germs of both knockouts, no apoptosis was observed according to morphological (haematoxylin-eosin) as well as biochemical criteria (TUNEL). Morphology of the mutant tooth germs, however, was not changed. Additionally, knockout mice showed no changes in proliferation compared to wild type mice. According to ou (en)
- Během vývoje molárů se vyskytuje charakteristická apoptosa, která nám napovídá, že při odontogenezi hraje buněčná smrt několik úloh. Přesto je však jen málo známo o molekulárním mechanismu dentální apoptosy. V této studii bylo použito vyblokování apaf-1 a caspase-9, aby se odhalilo jejich zapojení do procesu apoptosy během časného vývoje zubů, s důrazem především na jejich funkci v apoptické eliminaci buněk primárního sklovinného uzlu. Byla zkoumána morfologie, proliferace a apoptosa zubního zárodku moláru na frontálních histologických řezech myších hlav v 15,5 dni embryonálníhoi vývoje (ED), ve stádiu, kdy primární sklovinný uzel se apoptoticky eliminuje. Při vyblokování obou nebyla pozorována apoptosa na zubních zárodcích molárů ani z hlediska morfologického (hematoxylin-eosin), ani z hlediska biochemického (TUNEL). Morfologie mutantních zubních zárodků však nebyla změněna. Navíc se u myší s vyblokováním neukázaly změny v proliferaci ve srovnání s polní myší. Z našich výzkumů vyblokovaných embryí (cs)
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| Title
| - Primary enamel knot cell death in Apaf-1 and caspase-9 deficient mice
- Smrt buněk primárního sklovinného uzlu u myší s deficiencí Apaf-1 a caspase-9 (cs)
- Primary enamel knot cell death in Apaf-1 and caspase-9 deficient mice (en)
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| skos:prefLabel
| - Primary enamel knot cell death in Apaf-1 and caspase-9 deficient mice
- Smrt buněk primárního sklovinného uzlu u myší s deficiencí Apaf-1 a caspase-9 (cs)
- Primary enamel knot cell death in Apaf-1 and caspase-9 deficient mice (en)
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| skos:notation
| - RIV/62157124:16170/07:00001413!RIV08-AV0-16170___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(GA304/04/0101), P(KJB500450503), P(OC B23.001), Z(AV0Z50450515)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16170/07:00001413
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - apoptosis; knockout; caspase-9; apaf-1; dental (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Míšek, Ivan
- Setkova, Jana
- Tucker, Abigail
- Matalova, Eva
- Sharpe, Paul
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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