About: Ontogenetic development of innate immunity

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Pig. Developmental immunology employs the pig model because of character of epitheliochorial placentation impermeable for mother immunoglobulins. Thus studies of spontaneous development of effector defence mechanisms have excellent advantage. We focused on innate immune responses mediated by natural killer (NK) cells, when former data were without evidence of NK cytotoxicity with conventional target cells. We used for fetal NK cytotoxicity experiments special targets - combination of xeno - and isogeneous surface determinants, i.e. rat C6 glioma cells (t -C6 cells) transfected with pig T lymphocyte determinants. Our measurements starting pig fetal day 100 up to postnatal day 35 proved NK activity with t - C6 cells significantly higher in comparison with conventional targets cells (K 562). Development of innate immune responses with NK cells is supported by high increase of bactericidal activity of piglet phagocytes against S. typhimurium, LT2 type. Goat. Goat as a ruminant model, was chosen becau Pig. Developmental immunology employs the pig model because of character of epitheliochorial placentation impermeable for mother immunoglobulins. Thus studies of spontaneous development of effector defence mechanisms have excellent advantage. We focused on innate immune responses mediated by natural killer (NK) cells, when former data were without evidence of NK cytotoxicity with conventional target cells. We used for fetal NK cytotoxicity experiments special targets - combination of xeno - and isogeneous surface determinants, i.e. rat C6 glioma cells (t -C6 cells) transfected with pig T lymphocyte determinants. Our measurements starting pig fetal day 100 up to postnatal day 35 proved NK activity with t - C6 cells significantly higher in comparison with conventional targets cells (K 562). Development of innate immune responses with NK cells is supported by high increase of bactericidal activity of piglet phagocytes against S. typhimurium, LT2 type. Goat. Goat as a ruminant model, was chosen becau (en) Cílem práce bylo sledování vývoje přirozené imunity u selat a kůzlat. Pozornost byla zaměřena na imunitní reakce, zprostředkované především NK buňkami. Údaje popisující tuto oblast přirozené imunity jsou prozatím velmi omezené. (cs)
Title	Ontogenetic development of innate immunity Ontogenetic development of innate immunity (en) Ontogenetický vývoj vrozené imunity (cs)
skos:prefLabel	Ontogenetic development of innate immunity Ontogenetic development of innate immunity (en) Ontogenetický vývoj vrozené imunity (cs)
skos:notation	RIV/62157124:16170/06:00000595!RIV07-GA0-16170___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA524/05/0267), Z(MSM6215712403)
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Kovářů, F. Malá, Simona Matalová, Eva
http://linked.open.../riv/druhVysledku	M - Uspořádání (zorganizování) konference
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Fakulta veterinárního lékařství
http://linked.open...dnocenehoVysledku	490599
http://linked.open...ai/riv/idVysledku	RIV/62157124:16170/06:00000595
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	NK cells (en)
http://linked.open.../riv/klicoveSlovo	NK cells
http://linked.open...ontrolniKodProRIV	[E8B6309DACB2]
http://linked.open...v/mistoKonaniAkce	Freiburg, Deutschland
http://linked.open...in/vavai/riv/obor	EC
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...ocetUcastnikuAkce	500 (xsd:int)
http://linked.open...nichUcastnikuAkce	500 (xsd:int)
http://linked.open...vavai/riv/projekt	Mechanisms related to ontogenesis of immune system and their modulations
http://linked.open...UplatneniVysledku	2006
http://linked.open...iv/statKonaniAkce	FR - Francouzská republika
http://linked.open...iv/tvurceVysledku	Lojek, Antonín Fišerová, Anna Matalová, Eva Malá, Simona Kovářů, František Kovářů, Hana Kuldová, Markéta
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/ukonceniAkce	2006-09-12 (xsd:date)
http://linked.open.../riv/zahajeniAkce	2006-09-10 (xsd:date)
http://linked.open...n/vavai/riv/zamer	Active creation of health, yield and performance of the large animals
http://localhost/t...ganizacniJednotka	16170

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