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| Description
| - Cílem práce bylo zhodnotit účinek dextranu železa na chemiluminescenci neutrofilních granulocytů a ukazatele vnitřního prostředí selat. Selatům v experimentální skupině (n=16) bylo aplikováno i.m. 2000 mg Fe3+ ve formě dextranu železa. Selatům v kontrolní skupině (n=13) bylo aplikováno stejné množství fyziologického roztoku. Krev byla odebrána před aplikací a 1, 4 a 24 hodin poté. Aplikace železa v experimentální skupině měla za následek desetinásobně větší koncentraci železa v plazmě. Mezi oběma skupinami nebyly zjištěny žádné rozdíly v PMA a OZP stimulované chemiluminiscenci. Zvýšené aktivity CK, AST a LDH indikují poškození svaloviny v místě aplikace. Nebyly zjištěny změny indikující poškození jater a ledvin. Výsledky práce vypovídají o dobré bezpečnosti dextranu železa po parenterální aplikaci (cs)
- The objective of the study was to evaluate effect of an acute iron dextran on polymorphonuclear cells chemiluminescence and indices of inner environmemt in piglets. The piglets in experimental group (n = 16) were given 2000 mg (20 ml) Fe3+ in the form of iron dextran i.m. The piglets in control group (n = 13) were given the same amount of physiological solution. The blood was taken before application, 1, 4 and 24 hours thereafter. Iron application resulted in ten times higher concentration of iron in blood plasma in experimental group. No differences in PMA- and OZP- stimulated chemiluminescence were recorded between the two groups. The increased activities of CK, AST and LDH are indicative of muscle injury at the application site. No changes indicating liver or kidney injury were reported. Our study provides evidence of a good safety of iron dextran after parenteral administration.
- The objective of the study was to evaluate effect of an acute iron dextran on polymorphonuclear cells chemiluminescence and indices of inner environmemt in piglets. The piglets in experimental group (n = 16) were given 2000 mg (20 ml) Fe3+ in the form of iron dextran i.m. The piglets in control group (n = 13) were given the same amount of physiological solution. The blood was taken before application, 1, 4 and 24 hours thereafter. Iron application resulted in ten times higher concentration of iron in blood plasma in experimental group. No differences in PMA- and OZP- stimulated chemiluminescence were recorded between the two groups. The increased activities of CK, AST and LDH are indicative of muscle injury at the application site. No changes indicating liver or kidney injury were reported. Our study provides evidence of a good safety of iron dextran after parenteral administration. (en)
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| Title
| - Effect on an acute iron overdose on PMN cells chemiluminescence and indices on inner environment in a swine model.
- Effect on an acute iron overdose on PMN cells chemiluminescence and indices on inner environment in a swine model. (en)
- Vliv akutního předávkování železem na chemiluminescenci neutrofilních granulocytů a ukazatele vnitřního prostředí u prasat (cs)
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| skos:prefLabel
| - Effect on an acute iron overdose on PMN cells chemiluminescence and indices on inner environment in a swine model.
- Effect on an acute iron overdose on PMN cells chemiluminescence and indices on inner environment in a swine model. (en)
- Vliv akutního předávkování železem na chemiluminescenci neutrofilních granulocytů a ukazatele vnitřního prostředí u prasat (cs)
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| skos:notation
| - RIV/62157124:16170/06:00000530!RIV07-MSM-16170___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62157124:16170/06:00000530
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Lojek, Antonín
- Svoboda, Martin
- Drábek, Josef
- Polášková, Jana
- Ficek, Radek
- Hiemer, Jiří
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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