About: Involvement of adenosine receptors in NK cell-mediated cytotoxicity in different mammalian species

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Začlenění adenosiových receptorů do NK cytotoxicity u různých druhů savců (cs) Neuroimmune modulation depends on many molecular structures, where the substantial role plays adenosine receptors in cooperation with dopamine. This is especially exerted when the system undergo stressful conditions or tumor target cell recognition. Our study was designed to assess the effect of adenosine A 1 (CCPA), A 3 (NECA), and A 2A (CPCA) receptor agonists in natural killer (NK) cell-mediated cytotoxicity across several mammalian species (mouse, rat, human and pig). The experimental models of restraint stress or transplanted tumors under dopaminergic impact in mice were followed. An inhibitory action of A 2A agonist at high concentration (10-5M) were demonstrated, while A 1 and A 3 adenosine agonists don´t influence significantly the NK cells effector function. On the other hand, low concentrations of A 2A agonist stimulated the cytotoxicity in healthy unconditioned animals, and contrary evoked inhibition under stress of tumor pressure. Moreover, the final effects of adenosine receptor agonist Neuroimmune modulation depends on many molecular structures, where the substantial role plays adenosine receptors in cooperation with dopamine. This is especially exerted when the system undergo stressful conditions or tumor target cell recognition. Our study was designed to assess the effect of adenosine A 1 (CCPA), A 3 (NECA), and A 2A (CPCA) receptor agonists in natural killer (NK) cell-mediated cytotoxicity across several mammalian species (mouse, rat, human and pig). The experimental models of restraint stress or transplanted tumors under dopaminergic impact in mice were followed. An inhibitory action of A 2A agonist at high concentration (10-5M) were demonstrated, while A 1 and A 3 adenosine agonists don´t influence significantly the NK cells effector function. On the other hand, low concentrations of A 2A agonist stimulated the cytotoxicity in healthy unconditioned animals, and contrary evoked inhibition under stress of tumor pressure. Moreover, the final effects of adenosine receptor agonist (en)
Title	Involvement of adenosine receptors in NK cell-mediated cytotoxicity in different mammalian species Involvement of adenosine receptors in NK cell-mediated cytotoxicity in different mammalian species (en) Začlenění adenosiových receptorů do NK cytotoxicity u různých druhů savců (cs)
skos:prefLabel	Involvement of adenosine receptors in NK cell-mediated cytotoxicity in different mammalian species Involvement of adenosine receptors in NK cell-mediated cytotoxicity in different mammalian species (en) Začlenění adenosiových receptorů do NK cytotoxicity u různých druhů savců (cs)
skos:notation	RIV/62157124:16170/04:00000207!RIV06-GA0-16170___
http://linked.open.../vavai/riv/strany	20P
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA304/01/0850)
http://linked.open...vai/riv/dodaniDat	2006
http://linked.open...aciTvurceVysledku	Kovářů, F.
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Fakulta veterinárního lékařství
http://linked.open...dnocenehoVysledku	568950
http://linked.open...ai/riv/idVysledku	RIV/62157124:16170/04:00000207
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	adenosine receptors; NK cells (en)
http://linked.open.../riv/klicoveSlovo	NK cells adenosine receptors
http://linked.open...ontrolniKodProRIV	[51B92977113B]
http://linked.open...v/mistoKonaniAkce	Praha
http://linked.open...i/riv/mistoVydani	neudán
http://linked.open...i/riv/nazevZdroje	80. fyziologické dny
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Ontogenetic development of immune systém cdells and their surface structures
http://linked.open...UplatneniVysledku	2004
http://linked.open...iv/tvurceVysledku	Fišerová, Anna Starec, M. Pospíšil, M. Lukšan, O. Kovářů, František Kovářů, Hana Kuldová, M. Páv, M. Vannucci, L.
http://linked.open...vavai/riv/typAkce	CST - Celostátní
http://linked.open.../riv/zahajeniAkce	2004-02-03 (xsd:date)
issn	6551-2135
number of pages	1 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Neuveden
http://localhost/t...ganizacniJednotka	16170

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