About: Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio

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About: Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	: The aim of this work was to evaluate the response of dogs with pituitary-dependent hyperadrenocorticism to treatment with mitotane. The relationship between duration of initial phase of therapy and the initial value of urine cortisol/creatinine ratio(UCCR) was studied. All 14 dogs with pituitary-dependent hyperadrenocorticism were treated. Therapeutic protocol of selective adrenocorticolysis was used. The induction dose of mitotane was 25 mg/kg daily. The length of initial phase of therapy was dete rmined individually on the basis of cortisol production changes, which were monitored by immunoreactive cortisol in urine (UCCR) every 2 - 5 days during the initial phase of treatment. High-dose dexamethasone suppression test was used to differentiate between the pituitary-dependent and adrenal-dependent form of the disease, and the UCCR was measured after dexamethasone suppression. The value of the initial UCCR fluctuated between 58-586 x 10-6 , the median of UCCR was 138 x 10-6 . Initial phase of ther : The aim of this work was to evaluate the response of dogs with pituitary-dependent hyperadrenocorticism to treatment with mitotane. The relationship between duration of initial phase of therapy and the initial value of urine cortisol/creatinine ratio(UCCR) was studied. All 14 dogs with pituitary-dependent hyperadrenocorticism were treated. Therapeutic protocol of selective adrenocorticolysis was used. The induction dose of mitotane was 25 mg/kg daily. The length of initial phase of therapy was dete rmined individually on the basis of cortisol production changes, which were monitored by immunoreactive cortisol in urine (UCCR) every 2 - 5 days during the initial phase of treatment. High-dose dexamethasone suppression test was used to differentiate between the pituitary-dependent and adrenal-dependent form of the disease, and the UCCR was measured after dexamethasone suppression. The value of the initial UCCR fluctuated between 58-586 x 10-6 , the median of UCCR was 138 x 10-6 . Initial phase of ther (en)
Title	Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio (en)
skos:prefLabel	Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio Evaluation of pituitary-dependent hyperadrenocorticism response to mitotane treatment in dogs. Length of initial phase of treatment in relation to initial value of urine cortisol/creatinine ratio (en)
skos:notation	RIV/62157124:16170/01:00000745!RIV/2002/MSM/161702/N
http://linked.open.../vavai/riv/strany	313 - 320
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM 161700001)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2002
http://linked.open...aciTvurceVysledku	Svoboda, Miroslav Kolevská, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Veterinární a farmaceutická univerzita Brno / Fakulta veterinárního lékařství
http://linked.open...dnocenehoVysledku	679731
http://linked.open...ai/riv/idVysledku	RIV/62157124:16170/01:00000745
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	o,p´- DDD, immunoreactive cortisol in urine, selective adrenocorticolysis, iatrogenic hypoadrenocorticism (en)
http://linked.open.../riv/klicoveSlovo	o iatrogenic hypoadrenocorticism immunoreactive cortisol in urine p´- DDD selective adrenocorticolysis
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[BBB45F232B9A]
http://linked.open...i/riv/nazevZdroje	Acta veterinaria
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...UplatneniVysledku	2001
http://linked.open...v/svazekPeriodika	70
http://linked.open...iv/tvurceVysledku	Svoboda, Miroslav Kolevská, Jana
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20161700001
issn	0001-7213
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	16170

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