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| rdf:type
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| Description
| - To detect prostate carcinoma, prostatic specific antigen (PSA) is mostly used. However diagnostics of this tumour disease can become more precise using other types of molecules [1]. In this study we aimed at determination of reduced (GSH) and oxidized (GSSG) glutathione and its ratio and level of metallothionein in blood of patients with prostate carcinoma. The obtained results were correlated with PSA levels determined in blood of patients. Analyses were performed in 35 patients with prostate cancer at the age of 54 to 79 years with an average of 66 years and in 8 healthy subjects who formed the control group. PSA levels in patients ranged from 1.4 to 6.4 ng*ml-1 with an average of 2.4 ng*ml-1, GSH/GSSG from 0.6 to 6.7 with an average of 4.3 and metallothionein content ranged from 0.97 to 2.42 uM with an average of 1.91 uM. In the control group PSA values ranged from 0.06 to 0.14 ng*ml-1 with an average of 0.11 ng*ml-1, GSH/GSSG from 7.8 to 13.8 with an average of 9.4 and metallothionein content ranged from 0.51 to 1.04 uM with an average of 0.82 uM. The correlation between PSA and GSH/GSSG reached R2 = 0.378. The value of PSA and metallothionein content was correlated with R2 = 0.589. However, there were observed large differences between the values of the ratio of GSH and GSSG which were significantly (P <0.01) higher in the control group than in the group of patients with prostate cancer. Also, differences in content between metallothionein control group and a group of patients were highly significant (P <0.01).
- To detect prostate carcinoma, prostatic specific antigen (PSA) is mostly used. However diagnostics of this tumour disease can become more precise using other types of molecules [1]. In this study we aimed at determination of reduced (GSH) and oxidized (GSSG) glutathione and its ratio and level of metallothionein in blood of patients with prostate carcinoma. The obtained results were correlated with PSA levels determined in blood of patients. Analyses were performed in 35 patients with prostate cancer at the age of 54 to 79 years with an average of 66 years and in 8 healthy subjects who formed the control group. PSA levels in patients ranged from 1.4 to 6.4 ng*ml-1 with an average of 2.4 ng*ml-1, GSH/GSSG from 0.6 to 6.7 with an average of 4.3 and metallothionein content ranged from 0.97 to 2.42 uM with an average of 1.91 uM. In the control group PSA values ranged from 0.06 to 0.14 ng*ml-1 with an average of 0.11 ng*ml-1, GSH/GSSG from 7.8 to 13.8 with an average of 9.4 and metallothionein content ranged from 0.51 to 1.04 uM with an average of 0.82 uM. The correlation between PSA and GSH/GSSG reached R2 = 0.378. The value of PSA and metallothionein content was correlated with R2 = 0.589. However, there were observed large differences between the values of the ratio of GSH and GSSG which were significantly (P <0.01) higher in the control group than in the group of patients with prostate cancer. Also, differences in content between metallothionein control group and a group of patients were highly significant (P <0.01). (en)
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| Title
| - Association of PSA level with thiols content in patients with prostate carcinoma
- Association of PSA level with thiols content in patients with prostate carcinoma (en)
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| skos:prefLabel
| - Association of PSA level with thiols content in patients with prostate carcinoma
- Association of PSA level with thiols content in patients with prostate carcinoma (en)
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| skos:notation
| - RIV/62156489:43210/12:00198376!RIV13-GA0-43210___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62156489:43210/12:00198376
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - glutathion; prostate carcinoma; PSA (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - International Journal of Molecular Medicine
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Adam, Vojtěch
- Eckschlager, Tomáš
- Hynek, David
- Kizek, René
- Křížková, Soňa
- Masařík, Michal
- Sochor, Jiří
- Stiborová, Marie
- Zítka, Ondřej
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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