About: From amino acids to proteins as targets for metal-based drugs

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About: From amino acids to proteins as targets for metal-based drugs Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Metallomics and metalloproteomics are emerging fields addressing the role, uptake, transport and storage of trace metals ions both toxic and essential for an organism. Research areas related to the understanding of the mechanisms of life processes associated to metals are covered. Similarly to the genome and proteome terms, metallome was introduced to refer to metalloproteins, metalloenzymes and other metal-containing biomolecules in a biological system. This review aims to give an overview of metal ions behaviour in organisms. The interactions of metals with biomolecules such as amino acids, peptides and protein are the main focus. Special attention is paid to the application of nanotechnology-based techniques using these interactions for medical purposes such as diagnostics, imaging and therapy. Metallomics and metalloproteomics are emerging fields addressing the role, uptake, transport and storage of trace metals ions both toxic and essential for an organism. Research areas related to the understanding of the mechanisms of life processes associated to metals are covered. Similarly to the genome and proteome terms, metallome was introduced to refer to metalloproteins, metalloenzymes and other metal-containing biomolecules in a biological system. This review aims to give an overview of metal ions behaviour in organisms. The interactions of metals with biomolecules such as amino acids, peptides and protein are the main focus. Special attention is paid to the application of nanotechnology-based techniques using these interactions for medical purposes such as diagnostics, imaging and therapy. (en)
Title	From amino acids to proteins as targets for metal-based drugs From amino acids to proteins as targets for metal-based drugs (en)
skos:prefLabel	From amino acids to proteins as targets for metal-based drugs From amino acids to proteins as targets for metal-based drugs (en)
skos:notation	RIV/62156489:43210/12:00185289!RIV13-GA0-43210___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED1.1.00/02.0068), P(GA102/08/1546), P(GAP301/10/0356), P(IAA401990701), P(KAN208130801)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Ryvolová, Markéta Eckschlager, Tomáš Adam, Vojtěch Hubálek, Jaromír Kizek, René Zítka, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mendelova univerzita v Brně / Agronomická fakulta
http://linked.open...dnocenehoVysledku	137282
http://linked.open...ai/riv/idVysledku	RIV/62156489:43210/12:00185289
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	metallomics; protein; amino acid (en)
http://linked.open.../riv/klicoveSlovo	protein amino acid metallomics
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[9A9BDCBE1152]
http://linked.open...i/riv/nazevZdroje	Current Drug Metabolism
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Central european institute of technology Study of contribution of different DNA-damaging mechanisms to toxicity of cytostatics to human chemosensitive and chemoresistant neuroblastomas Study of binding of platinum cytostatics to DNA structure; Influence of metallothionein New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED) Miniaturized intelligent systems and nanostructured elektrodes for chemical, biological, and pharmaceutical applications (NANIMEL)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	13
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Eckschlager, Tomáš Hubálek, Jaromír Kizek, René Ryvolová, Markéta Zítka, Ondřej
issn	1389-2002
number of pages	15 (xsd:int)
http://localhost/t...ganizacniJednotka	43210

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