About: Determination of sarcosine as possible tumour marker of prostate tumours

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Amino acid sarcosine, known also as N-methylglycine, may be established as new very important marker in prostate malignant tumours and may be determined by very simple test. Cancer of prostate is one of the most incident types of malignant tumours in men. More than one thousand men in Czech Republic die due to this disease. As well as in the case of other malignant tumours, for initiation of treatment well timed diagnosis of disease is necessary. For determination of sarcosine we employed the ionex chromatography with postcolumn derivatization by ninhydrin. We achieved the calibration curve linearity R2=0.9984 with limit of detection 500nM. Moreover we confirmed that the calibration was not affected by presence of another aminoacids and ensure that selectivity of separation is near to 99% efficiency. Amino acid sarcosine, known also as N-methylglycine, may be established as new very important marker in prostate malignant tumours and may be determined by very simple test. Cancer of prostate is one of the most incident types of malignant tumours in men. More than one thousand men in Czech Republic die due to this disease. As well as in the case of other malignant tumours, for initiation of treatment well timed diagnosis of disease is necessary. For determination of sarcosine we employed the ionex chromatography with postcolumn derivatization by ninhydrin. We achieved the calibration curve linearity R2=0.9984 with limit of detection 500nM. Moreover we confirmed that the calibration was not affected by presence of another aminoacids and ensure that selectivity of separation is near to 99% efficiency. (en)
Title	Determination of sarcosine as possible tumour marker of prostate tumours Determination of sarcosine as possible tumour marker of prostate tumours (en)
skos:prefLabel	Determination of sarcosine as possible tumour marker of prostate tumours Determination of sarcosine as possible tumour marker of prostate tumours (en)
skos:notation	RIV/62156489:43210/10:00184603!RIV12-AV0-43210___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GP301/09/P436), P(KAN208130801)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Cernei, Natalia Vladimirovna Babula, Petr Masařík, Michal Kizek, René Zítka, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Mendelova univerzita v Brně / Agronomická fakulta
http://linked.open...dnocenehoVysledku	253803
http://linked.open...ai/riv/idVysledku	RIV/62156489:43210/10:00184603
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ninhydrin; sarcosine; prostate cancer (en)
http://linked.open.../riv/klicoveSlovo	prostate cancer sarcosine ninhydrin
http://linked.open...odStatuVydavatele	IN - Indická republika
http://linked.open...ontrolniKodProRIV	[CD94B9A9E99B]
http://linked.open...i/riv/nazevZdroje	Journal of Biochemical Technology
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Metallothionein analysis in prostate carcinoma at DNA, RNA and protein level. New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED)
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	2
http://linked.open...iv/tvurceVysledku	Babula, Petr Cernei, Natalia Vladimirovna Gumulec, Jaromír Kizek, René Masařík, Michal Zítka, Ondřej
issn	0974-2328
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	43210

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