About: Investigation of a role of metallothionein in resistance on platinum based cytostatics     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
Description
  • In this work, we employed electroanalytical methods for determination of metallothionein (MT) in cisplatin or carboplatin sensitive and resistant neuroblastoma cell lines, blood serum of patients with head and neck cancer or retinoblastoma, and of rats treated with cisplatin with respect to discuss the role of MT in formation of resistance on treatment with heavy metal based cytostatics. In addition, we were interested in the effect of cisplatin or carboplatin treatment of patients with a tumour disease. At patients with tumour in head and neck area treated with cisplatin we observed that the level of MT was going higher due to administration of the drug. However, at retinoblastoma patients treated with carboplatin we observed various phenomena including decreasing, increasing or no changes in MT level.
  • In this work, we employed electroanalytical methods for determination of metallothionein (MT) in cisplatin or carboplatin sensitive and resistant neuroblastoma cell lines, blood serum of patients with head and neck cancer or retinoblastoma, and of rats treated with cisplatin with respect to discuss the role of MT in formation of resistance on treatment with heavy metal based cytostatics. In addition, we were interested in the effect of cisplatin or carboplatin treatment of patients with a tumour disease. At patients with tumour in head and neck area treated with cisplatin we observed that the level of MT was going higher due to administration of the drug. However, at retinoblastoma patients treated with carboplatin we observed various phenomena including decreasing, increasing or no changes in MT level. (en)
  • V této práci jeme užily elektrochemickou metodu pro stanovení metalothioneinu v senzitivní a rezistentní neuroblastomové buněčné lini ke karboplatině a cisplatině, v krevním séru pacientů s nádory krku a hlavy nebo retinoblastem a myších vystavených cisplatině. A zaměřili jsme se na roli metalothioneinu ve vzniku rezistence k léčbě založené na cytostaticích na bázi těžkých kovů. Zjistili jsme zajímavý efekt u cisplatinou a karboplatinou léčených pacientů s nádorovým onemocněním. Pacienti s nádory halvi a krku měli po léčbě vyšší hladinu metalothioeniunu, zatím co pacienti s retinoblastomem nastalo snížení, zvýšení a nebo žádná změna v obsahu MT. (cs)
Title
  • Investigation of a role of metallothionein in resistance on platinum based cytostatics
  • Investigation of a role of metallothionein in resistance on platinum based cytostatics (en)
  • Výzkum role metalothioneinu v rezistenci na platinová cytostaika (cs)
skos:prefLabel
  • Investigation of a role of metallothionein in resistance on platinum based cytostatics
  • Investigation of a role of metallothionein in resistance on platinum based cytostatics (en)
  • Výzkum role metalothioneinu v rezistenci na platinová cytostaika (cs)
skos:notation
  • RIV/62156489:43210/08:00133458!RIV09-AV0-43210___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(IAA401990701)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 373192
http://linked.open...ai/riv/idVysledku
  • RIV/62156489:43210/08:00133458
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • cisplatin; drugs resistant; carboplatina (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [B3752FF4A80F]
http://linked.open...i/riv/nazevZdroje
  • Toxicology Letters
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 180
http://linked.open...iv/tvurceVysledku
  • Adam, Vojtěch
  • Eckschlager, Tomáš
  • Hraběta, Jan
  • Húska, Dalibor
  • Kizek, René
  • Křížková, Soňa
  • Průša, Richard
  • Fabrik, Ivo
  • Kukacka, J.
issn
  • 0378-4274
number of pages
http://localhost/t...ganizacniJednotka
  • 43210
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 38 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software