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Description
| - In the present paper we employed adsorptive transfer stripping technique coupled with chronopotentiometric stripping analysis for determination of metallothionein (MT) in tumor cell lines and differential pulse voltammetry Brdicka reaction for determination of MT in blood serum of patients with head and neck cancer or retinoblastoma, and of rats treated with cisplatin with respect to discuss the role of MT in formation of resistance on treatment with heavy metal based cytostatics. The cisplatin or carboplatin sensitive and resistant neuroblastoma cell lines were derived from the maternal cell line isolated from the bone metastasis of patients with neuroblastoma. Based on the results obtained it can be concluded that level of MT increases with higher dose of platinum based
- In the present paper we employed adsorptive transfer stripping technique coupled with chronopotentiometric stripping analysis for determination of metallothionein (MT) in tumor cell lines and differential pulse voltammetry Brdicka reaction for determination of MT in blood serum of patients with head and neck cancer or retinoblastoma, and of rats treated with cisplatin with respect to discuss the role of MT in formation of resistance on treatment with heavy metal based cytostatics. The cisplatin or carboplatin sensitive and resistant neuroblastoma cell lines were derived from the maternal cell line isolated from the bone metastasis of patients with neuroblastoma. Based on the results obtained it can be concluded that level of MT increases with higher dose of platinum based (en)
- Cílem této práce bylo využít adsorbtivní přenosovou techniku rozpouštěcí chronopotenciometrické analýzi pro stanovení metalothioneinu v krevním séru pacientů s nádory krku a hlavy případně pacientů s retoblastomema a myší po aplikaci cysplatiny. Dále stanovení metalothioneinu v nádorových buněčných liniích. Bůněčné linie byly izolovány od pacientů s neuroblastomi. Na základě výsledků jsem vyslovili závěr, že hladina metalothioneinu se zvyšuje po vyší dávce cisplatiny. (cs)
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Title
| - Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease
- Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease (en)
- Elektrochemické techniky pro stanovení metalothioneinu v tumorových buněčných liniích a pacientů s nádorovým onemocněním (cs)
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skos:prefLabel
| - Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease
- Employment of electrochemical techniques for metallothionein determination in tumour cell lines and patients with a tumor disease (en)
- Elektrochemické techniky pro stanovení metalothioneinu v tumorových buněčných liniích a pacientů s nádorovým onemocněním (cs)
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skos:notation
| - RIV/62156489:43210/08:00133063!RIV09-AV0-43210___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/62156489:43210/08:00133063
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - cisplatin; metallothionein (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - DE - Spolková republika Německo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Adam, Vojtěch
- Hubálek, Jaromír
- Húska, Dalibor
- Kizek, René
- Křížková, Soňa
- Průša, Richard
- Trnková, Libuše
- Fabrik, Ivo
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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