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| rdf:type
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| Description
| - Four classes of metallothioneins (MT1, MT2, MT3 and MT4) have been described until now. Human metallothioneins belongs to I. class of metallothioneins (MT1) and are encoded by gene family with 10 isoforms. Due to their high affinity to heavy metals e.g. zinc, copper and/or cadmium, homeostatic control and detoxification of the metals are their main physiological function at evolutionary different animal organisms. Moreover, it has been discussed that expression of MT could relate with resistance to a treatment by anticancer drugs based on heavy metals, most of all, platinum group metals. The aim of this work was to investigate interactions of MT with cisplatin and to determine a content of MT at tumour cell lines. We used cell lines obtained from neuroblastome that were cisplatin sensitive (UKF-NB 2, UKF-NB 3 and UKF-NB 4) and/or cisplatin resistant (UKF-NB 2 CDDP, UKF-NB 3 CDDP and UKF-NB 4 CDDP). The samples were analysed with AUTOLAB Analyser (EcoChemie, Netherlands). The supporting electrolyte c
- Four classes of metallothioneins (MT1, MT2, MT3 and MT4) have been described until now. Human metallothioneins belongs to I. class of metallothioneins (MT1) and are encoded by gene family with 10 isoforms. Due to their high affinity to heavy metals e.g. zinc, copper and/or cadmium, homeostatic control and detoxification of the metals are their main physiological function at evolutionary different animal organisms. Moreover, it has been discussed that expression of MT could relate with resistance to a treatment by anticancer drugs based on heavy metals, most of all, platinum group metals. The aim of this work was to investigate interactions of MT with cisplatin and to determine a content of MT at tumour cell lines. We used cell lines obtained from neuroblastome that were cisplatin sensitive (UKF-NB 2, UKF-NB 3 and UKF-NB 4) and/or cisplatin resistant (UKF-NB 2 CDDP, UKF-NB 3 CDDP and UKF-NB 4 CDDP). The samples were analysed with AUTOLAB Analyser (EcoChemie, Netherlands). The supporting electrolyte c (en)
- Byli popsány 4 třídy metalothioneinu. Lidský metalothionein patří do první skupiny a jsou kódovány rodinou s deseti isofomami. Pro jejich schopnosti vytvářet komplexy s kovy jako je zinek, kadmium apod. má důležitou fyziologickou funkci v regulaci hladin těchto iontu v organizmu. Je pravděpodobné, že sehrávají úlohu v nádorové rezistenci při léčbě platinovými cytostatiky. V této práci jsme zkoumali interakci platinových cytostatik s MT a koncentraci MT u nádorových liniích. My jsme použily buněčné linie z neuroblastomu a to linie rezistentní (UKF-NB 2 CDDP, UKF-NB 3 CDDP and UKF-NB 4 CDDP) a senzitivní (UKF-NB 2, UKF-NB 3 and UKF-NB 4). Přítomnost cisplatiny u buněčných linií spustí tvorbu thiolových látek, jejich množství vzrostlo až o 1000% v porovnání s kontrolou.. (cs)
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| Title
| - Increase in content of metallothionein as marker of resistance to cisplatin treatment
- Význam zvýšení obsahu metalothioneinu v rezistenci k léčbě cisplatinou (cs)
- Increase in content of metallothionein as marker of resistance to cisplatin treatment (en)
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| skos:prefLabel
| - Increase in content of metallothionein as marker of resistance to cisplatin treatment
- Význam zvýšení obsahu metalothioneinu v rezistenci k léčbě cisplatinou (cs)
- Increase in content of metallothionein as marker of resistance to cisplatin treatment (en)
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| skos:notation
| - RIV/62156489:43210/06:00103447!RIV07-GA0-43210___
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62156489:43210/06:00103447
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - cancer; cisplatin; metallothionein (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Adam, Vojtěch
- Beklová, Miroslava
- Eckschlager, Tomáš
- Kizek, René
- Průša, Richard
- Svoboda, Michal
- Zítka, Ondřej
- Blaštík, Ondřej
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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