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| rdf:type
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| Description
| - Protein p53 is a transcriptional factor, which is routinely attendant in a cell at low concentrations. Alzheimer's disease, Parkinson's disease, cystic fibrosis, prion diseases, and many types of cancer are considered to be protein p53 conformation diseases. Most of them are also known as amyloidogenic diseases due to the occurrence of pathological accumulation of insoluble aggregates with fibrillar conformation. Some neuroblastomas, carcinomas, and myelomas show an abnormal accumulation of the wild-type tumor suppressor protein p53 either in the cytoplasm or in the nucleus of the cell. Electrochemical methods could be a suitable tool for study of very low protein p53 intracellular concentrations. In our work, protein p53 was analyzed by flow injection analysis coupled with electrochemical detector. The optimized method was rapid (less then five minutes) and sensitive (protein p53 detection limit was 45 amol). The sensitive detection method was applied to the study structural changes of protein p53 (d
- Protein p53 is a transcriptional factor, which is routinely attendant in a cell at low concentrations. Alzheimer's disease, Parkinson's disease, cystic fibrosis, prion diseases, and many types of cancer are considered to be protein p53 conformation diseases. Most of them are also known as amyloidogenic diseases due to the occurrence of pathological accumulation of insoluble aggregates with fibrillar conformation. Some neuroblastomas, carcinomas, and myelomas show an abnormal accumulation of the wild-type tumor suppressor protein p53 either in the cytoplasm or in the nucleus of the cell. Electrochemical methods could be a suitable tool for study of very low protein p53 intracellular concentrations. In our work, protein p53 was analyzed by flow injection analysis coupled with electrochemical detector. The optimized method was rapid (less then five minutes) and sensitive (protein p53 detection limit was 45 amol). The sensitive detection method was applied to the study structural changes of protein p53 (d (en)
- Protein p53 is a transcriptional factor, which is routinely attendant in a cell at low concentrations. Alzheimer's disease, Parkinson's disease, cystic fibrosis, prion diseases, and many types of cancer are considered to be protein p53 conformation diseases. Most of them are also known as amyloidogenic diseases due to the occurrence of pathological accumulation of insoluble aggregates with fibrillar conformation. Some neuroblastomas, carcinomas, and myelomas show an abnormal accumulation of the wild-type tumor suppressor protein p53 either in the cytoplasm or in the nucleus of the cell. Electrochemical methods could be a suitable tool for study of very low protein p53 intracellular concentrations. In our work, protein p53 was analyzed by flow injection analysis coupled with electrochemical detector. The optimized method was rapid (less then five minutes) and sensitive (protein p53 detection limit was 45 amol). The sensitive detection method was applied to the study structural changes of protein p53 (d (cs)
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| Title
| - Rychlá a senzitivní elektrochemická detekce nativní denaturované a agregované formy proteinu p53 (cs)
- Fast and sensitive electrochemical detection of native denaturated, and aggregated forms of tumor suppressor protein p53
- Fast and sensitive electrochemical detection of native denaturated, and aggregated forms of tumor suppressor protein p53 (en)
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| skos:prefLabel
| - Rychlá a senzitivní elektrochemická detekce nativní denaturované a agregované formy proteinu p53 (cs)
- Fast and sensitive electrochemical detection of native denaturated, and aggregated forms of tumor suppressor protein p53
- Fast and sensitive electrochemical detection of native denaturated, and aggregated forms of tumor suppressor protein p53 (en)
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| skos:notation
| - RIV/62156489:43210/04:00000630!RIV/2005/GA0/432105/N
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/62156489:43210/04:00000630
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Molecular biology of the cell
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
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| http://linked.open...iv/tvurceVysledku
| - Adam, Vojtěch
- Masařík, Michal
- Průša, Richard
- Jelen, František
- Potěšil, David
- Kízek, René
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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