About: Unusual recurrent rectal carcinoma: A cancer field theory viewpoint

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://biomed.papers.upol.cz/pdfs/bio/2014/03/16.pdf
Description	Aim: The rate of rectal cancer locoregional recurrence following radical surgery varies from 4% to 33%. Though the causes are unclear, likely factors include microscopic tumor residues in the lymphatics, positive resection margins and exfoliation of tumor cells and their subsequent intraluminar spread during operation. Other significant factors include type and technique of surgical procedure. Recently, it has been demonstrated that local recurrence may also be associated with the biological behaviour of the tumor and/or with the composition of the cellular microenvironment which creates optimal conditions for the growth and spread of tumor cells. Case report: The presented case here is interesting because the tumour recurred early following a curative surgical procedure with negative resection margins, without positive lymph nodes, without infiltration of the pelvic wall and without distant metastases. Conclusion: In patients with a determined risk of genetically altered tumor field encompassing epithelial or stromal changes, a different treatment strategy, including gene therapy, anti-inflammatory or anti-angiogenic therapy should be chosen to minimize increased tumor risk. Aim: The rate of rectal cancer locoregional recurrence following radical surgery varies from 4% to 33%. Though the causes are unclear, likely factors include microscopic tumor residues in the lymphatics, positive resection margins and exfoliation of tumor cells and their subsequent intraluminar spread during operation. Other significant factors include type and technique of surgical procedure. Recently, it has been demonstrated that local recurrence may also be associated with the biological behaviour of the tumor and/or with the composition of the cellular microenvironment which creates optimal conditions for the growth and spread of tumor cells. Case report: The presented case here is interesting because the tumour recurred early following a curative surgical procedure with negative resection margins, without positive lymph nodes, without infiltration of the pelvic wall and without distant metastases. Conclusion: In patients with a determined risk of genetically altered tumor field encompassing epithelial or stromal changes, a different treatment strategy, including gene therapy, anti-inflammatory or anti-angiogenic therapy should be chosen to minimize increased tumor risk. (en)
Title	Unusual recurrent rectal carcinoma: A cancer field theory viewpoint Unusual recurrent rectal carcinoma: A cancer field theory viewpoint (en)
skos:prefLabel	Unusual recurrent rectal carcinoma: A cancer field theory viewpoint Unusual recurrent rectal carcinoma: A cancer field theory viewpoint (en)
skos:notation	RIV/61989592:15510/14:33150605!RIV15-GA0-15510___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GAP304/10/1070)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Brychta, Tomáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Fakulta tělesné kultury
http://linked.open...dnocenehoVysledku	52053
http://linked.open...ai/riv/idVysledku	RIV/61989592:15510/14:33150605
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cellular microenvironment; recurrence; rectal cancer (en)
http://linked.open.../riv/klicoveSlovo	rectal cancer recurrence cellular microenvironment
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[B4186B1E00D7]
http://linked.open...i/riv/nazevZdroje	Biomedical Papers-Olomouc
http://linked.open...in/vavai/riv/obor	FJ
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of stem cells and factors of epithelial-mesenchymal transition in cancer stromal microenvironment alteration
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	158
http://linked.open...iv/tvurceVysledku	Brychta, Tomáš Skalický, Pavel Zbořil, Pavel Vomáčková, Katherine Bezděková, Michala Brychtová, Svetlana Vysloužil, Kamil
issn	1213-8118
number of pages	5 (xsd:int)
http://bibframe.org/vocab/doi	10.5507/bp.2012.091
http://localhost/t...ganizacniJednotka	15510

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