About: The effect of anthocyans on the expression of selected phase II xenobiotic-metabolizing enzymes in primary cultures of human hepatocytes.

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About: The effect of anthocyans on the expression of selected phase II xenobiotic-metabolizing enzymes in primary cultures of human hepatocytes. Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://pubs.rsc.org/en/content/articlepdf/2014/fo/c4fo00347k
Description	Anthocyans are biologically active constituents of various berry fruits and they are also contained in nutritional supplements derived from extracts or dry matter from berry fruits. In this study we evaluated the effects of anthocyans on the expression of selected drug-metabolizing phase II genes in primary cultures of human hepatocytes by qRT-PCR. Most of the tested anthocyanidins (6) and anthocyanins (21) did not induce the expression of mRNA of UGT1A/2B members in human hepatocytes. The same can be stated for expression of selected GST genes on the mRNA level. However, some of them e. g. cyanidin-3-O-rutinoside consistently decreased the level of GSTP1 mRNA in all tested cultures. In conclusion, most of the anthocyans did not affect the expression of selected phase II metabolizing enzymes in vitro. Anthocyans are biologically active constituents of various berry fruits and they are also contained in nutritional supplements derived from extracts or dry matter from berry fruits. In this study we evaluated the effects of anthocyans on the expression of selected drug-metabolizing phase II genes in primary cultures of human hepatocytes by qRT-PCR. Most of the tested anthocyanidins (6) and anthocyanins (21) did not induce the expression of mRNA of UGT1A/2B members in human hepatocytes. The same can be stated for expression of selected GST genes on the mRNA level. However, some of them e. g. cyanidin-3-O-rutinoside consistently decreased the level of GSTP1 mRNA in all tested cultures. In conclusion, most of the anthocyans did not affect the expression of selected phase II metabolizing enzymes in vitro. (en)
Title	The effect of anthocyans on the expression of selected phase II xenobiotic-metabolizing enzymes in primary cultures of human hepatocytes. The effect of anthocyans on the expression of selected phase II xenobiotic-metabolizing enzymes in primary cultures of human hepatocytes. (en)
skos:prefLabel	The effect of anthocyans on the expression of selected phase II xenobiotic-metabolizing enzymes in primary cultures of human hepatocytes. The effect of anthocyans on the expression of selected phase II xenobiotic-metabolizing enzymes in primary cultures of human hepatocytes. (en)
skos:notation	RIV/61989592:15310/14:33150561!RIV15-GA0-15310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GBP303/12/G163)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Pečová, Michaela Vrzal, Radim Dvořák, Zdeněk Kameníčková, Alžběta
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	13123
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/14:33150561
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	fractions; inhibition; proliferation; RAT; PI; induction; transcriptional regulation; UDP-glucuronosyltransferase; cancer-cell lines; glutathione-S-transferase (en)
http://linked.open.../riv/klicoveSlovo	cancer-cell lines UDP-glucuronosyltransferase PI inhibition RAT fractions glutathione-S-transferase induction proliferation transcriptional regulation
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[8880966B534D]
http://linked.open...i/riv/nazevZdroje	Food and Function
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of drug-dietary supplements interactions and nutrigenetics
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Dvořák, Zdeněk Vrzal, Radim Srovnalová, Alžběta Švécarová, Michaela
http://linked.open...ain/vavai/riv/wos	000341016500017
issn	2042-6496
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/c4fo00347k
http://localhost/t...ganizacniJednotka	15310

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