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  • We describe the synthesis of steroidal dendrimer conjugates of first and second generation with tetramethylene core and 5-hydroxy-isophtalic acid dimethyl ester as branching unit modified to incorporate ethynylestradiol or 17 alpha-estradiol as terminal units. The steroidal dendrimer conjugates, the free drug (steroids) and dendrimer were tested against a panel of cancer cell lines (CEM, MCF7, HeLa) and normal human fibroblast (BJ). The steroidal dendrimer conjugates of first generation exhibited cytotoxic activity and induced apoptosis in chronic leukemia (CEM) as resultant activation of caspase cascade which is mainly provoked in G2/M arrested cells.
  • We describe the synthesis of steroidal dendrimer conjugates of first and second generation with tetramethylene core and 5-hydroxy-isophtalic acid dimethyl ester as branching unit modified to incorporate ethynylestradiol or 17 alpha-estradiol as terminal units. The steroidal dendrimer conjugates, the free drug (steroids) and dendrimer were tested against a panel of cancer cell lines (CEM, MCF7, HeLa) and normal human fibroblast (BJ). The steroidal dendrimer conjugates of first generation exhibited cytotoxic activity and induced apoptosis in chronic leukemia (CEM) as resultant activation of caspase cascade which is mainly provoked in G2/M arrested cells. (en)
Title
  • Synthesis and antiproliferative activity of novel steroidal dendrimer conjugates
  • Synthesis and antiproliferative activity of novel steroidal dendrimer conjugates (en)
skos:prefLabel
  • Synthesis and antiproliferative activity of novel steroidal dendrimer conjugates
  • Synthesis and antiproliferative activity of novel steroidal dendrimer conjugates (en)
skos:notation
  • RIV/61989592:15310/13:33148036!RIV14-MSM-15310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ED0007/01/01), Z(MSM6198959216)
http://linked.open...iv/cisloPeriodika
  • 12-13
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 109459
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/13:33148036
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Ethynylestradiol; Antiproliferative activity; Steroidal dendrimer conjugates (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [DF1B1E154A16]
http://linked.open...i/riv/nazevZdroje
  • Steroids
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 78
http://linked.open...iv/tvurceVysledku
  • Strnad, Miroslav
  • Rárová, Lucie
  • Farfan, Norberto
  • Magana-Vergara, Nancy E
  • Santillan, Rosa
  • Soto-Castro, Delia
http://linked.open...ain/vavai/riv/wos
  • 000327287800013
http://linked.open...n/vavai/riv/zamer
issn
  • 0039-128X
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.steroids.2013.09.001
http://localhost/t...ganizacniJednotka
  • 15310
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