About: Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids     Goto   Sponge   NotDistinct   Permalink

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Description
  • Ergot alkaloids produced by the fungus Claviceps parasitizing on cereals, include three major groups: clavine alkaloids, D-lysergic acid and its derivatives and ergopeptines. These alkaloids are important substances for the pharmatech industry, where they are used for production of anti-migraine drugs, uterotonics, prolactin inhibitors, anti-Parkinson agents, etc. Production of ergot alkaloids is based either on traditional field cultivation of ergot-infected rye or on submerged cultures of the fungus in industrial fermentation plants. In 2010, the total production of these alkaloids in the world was about 20,000 kg, of which field cultivation contributed about 50%. This review covers the recent advances in understanding of the genetics and regulation of biosynthesis of ergot alkaloids, focusing on possible applications of the new knowledge to improve the production yield.
  • Ergot alkaloids produced by the fungus Claviceps parasitizing on cereals, include three major groups: clavine alkaloids, D-lysergic acid and its derivatives and ergopeptines. These alkaloids are important substances for the pharmatech industry, where they are used for production of anti-migraine drugs, uterotonics, prolactin inhibitors, anti-Parkinson agents, etc. Production of ergot alkaloids is based either on traditional field cultivation of ergot-infected rye or on submerged cultures of the fungus in industrial fermentation plants. In 2010, the total production of these alkaloids in the world was about 20,000 kg, of which field cultivation contributed about 50%. This review covers the recent advances in understanding of the genetics and regulation of biosynthesis of ergot alkaloids, focusing on possible applications of the new knowledge to improve the production yield. (en)
Title
  • Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids
  • Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids (en)
skos:prefLabel
  • Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids
  • Parasitic fungus Claviceps as a source for biotechnological production of ergot alkaloids (en)
skos:notation
  • RIV/61989592:15310/13:33147803!RIV14-GA0-15310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(ED0007/01/01), P(GAP501/12/0597)
http://linked.open...iv/cisloPeriodika
  • 1 - SI
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http://linked.open...aciTvurceVysledku
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  • 95372
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/13:33147803
http://linked.open...riv/jazykVysledku
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  • ergot alkaloids; production; genetic manipulation; biotechnology; Claviceps; Parasitic fungus (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [A2B707A78464]
http://linked.open...i/riv/nazevZdroje
  • Biotechnology Advances
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http://linked.open...ichTvurcuVysledku
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http://linked.open...v/svazekPeriodika
  • 31
http://linked.open...iv/tvurceVysledku
  • Frébort, Ivo
  • Frébortová, Jitka
  • Galuszka, Petr
  • Hanosová, Helena
http://linked.open...ain/vavai/riv/wos
  • 000315761200008
issn
  • 0734-9750
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.biotechadv.2012.01.005
http://localhost/t...ganizacniJednotka
  • 15310
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