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Description
  • In most clinical studies, patients are observed for extended time periods to evaluate influences in treatment such as drug treatment, approaches to surgery, etc. The primary event in these studies is death, relapse, adverse drug reaction, or development of a new disease. The follow-up time may range from few weeks to many years. Although these studies are long term, the number of observed events is small. Longitudinal studies have increased the importance of statistical methods for time-to event data that can incorporate time-dependent covariates. The Cox proportional regression model is a widely used method. It is a statistical technique for exploring the relationship between the survival of a patient and several explanatory variables. We apply Cox regression models when right censoring and delayed entry survival data are considered. Su and Wang (2012) stated that delayed entry produced biased sample. In the paper we present how re-sampling together with effect of delayed entry affect estimated parameters. The possibilities as well as limitations of this approach are demonstrated through the retrospective study of mitral valve replacement in children under 18 years.
  • In most clinical studies, patients are observed for extended time periods to evaluate influences in treatment such as drug treatment, approaches to surgery, etc. The primary event in these studies is death, relapse, adverse drug reaction, or development of a new disease. The follow-up time may range from few weeks to many years. Although these studies are long term, the number of observed events is small. Longitudinal studies have increased the importance of statistical methods for time-to event data that can incorporate time-dependent covariates. The Cox proportional regression model is a widely used method. It is a statistical technique for exploring the relationship between the survival of a patient and several explanatory variables. We apply Cox regression models when right censoring and delayed entry survival data are considered. Su and Wang (2012) stated that delayed entry produced biased sample. In the paper we present how re-sampling together with effect of delayed entry affect estimated parameters. The possibilities as well as limitations of this approach are demonstrated through the retrospective study of mitral valve replacement in children under 18 years. (en)
Title
  • Study of Bootstrap Estimates in Cox Regression Model with Delayed Entry
  • Study of Bootstrap Estimates in Cox Regression Model with Delayed Entry (en)
skos:prefLabel
  • Study of Bootstrap Estimates in Cox Regression Model with Delayed Entry
  • Study of Bootstrap Estimates in Cox Regression Model with Delayed Entry (en)
skos:notation
  • RIV/61989592:15310/13:33145899!RIV14-MSM-15310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 108655
http://linked.open...ai/riv/idVysledku
  • RIV/61989592:15310/13:33145899
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • mitral valve; observation study; delayed entry; Breslow method; Cox proportional regression model (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [11786954236B]
http://linked.open...i/riv/nazevZdroje
  • Acta Universitatis Palackianae Olomucensis, Facultas Rerum Naturalium, Mathematica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 52
http://linked.open...iv/tvurceVysledku
  • Bělašková, Silvie
  • Fišerová, Eva
  • Krupičková, Sylvia
issn
  • 0231-9721
number of pages
http://localhost/t...ganizacniJednotka
  • 15310
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