About: Fluorone dyes have binding sites on both cytoplasmic and extracellular domains of Na,K-ATPase

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About: Fluorone dyes have binding sites on both cytoplasmic and extracellular domains of Na,K-ATPase Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0005273612003781
Description	Combination of fluorescence techniques and molecular docking was used to monitor interaction of Na,K-ATPase and its large cytoplasmic loop connecting fourth and fifth transmembrane helices (C45) with fluorone dyes (i.e. eosin Y, 5(6)-carboxyeosin, rose bengal, fluorescein, and erythrosine B). Our data suggested that there are at least two binding sites for all used fluorone dyes, except of 5(6)-carboxyeosin. The first binding site is located on C45 loop, and it is sensitive to the presence of nucleotide. The other site is located on the extracellular part of the enzyme, and it is sensitive to the presence of Na + or K+ ions. Combination of fluorescence techniques and molecular docking was used to monitor interaction of Na,K-ATPase and its large cytoplasmic loop connecting fourth and fifth transmembrane helices (C45) with fluorone dyes (i.e. eosin Y, 5(6)-carboxyeosin, rose bengal, fluorescein, and erythrosine B). Our data suggested that there are at least two binding sites for all used fluorone dyes, except of 5(6)-carboxyeosin. The first binding site is located on C45 loop, and it is sensitive to the presence of nucleotide. The other site is located on the extracellular part of the enzyme, and it is sensitive to the presence of Na + or K+ ions. (en)
Title	Fluorone dyes have binding sites on both cytoplasmic and extracellular domains of Na,K-ATPase Fluorone dyes have binding sites on both cytoplasmic and extracellular domains of Na,K-ATPase (en)
skos:prefLabel	Fluorone dyes have binding sites on both cytoplasmic and extracellular domains of Na,K-ATPase Fluorone dyes have binding sites on both cytoplasmic and extracellular domains of Na,K-ATPase (en)
skos:notation	RIV/61989592:15310/13:33145503!RIV14-GA0-15310___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(EE2.3.20.0057), P(GAP301/10/0883), P(GPP205/11/P319)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Kubala, Martin Bazgier, Václav Janovská, Marika Berka, Karel Huličiak, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	75366
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/13:33145503
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Time-resolved fluorescence; Na,K-ATPase; Fluorone dyes; Fluorescence quenching; C45 loop; Binding sites (en)
http://linked.open.../riv/klicoveSlovo	Fluorescence quenching K-ATPase Binding sites C45 loop Fluorone dyes Time-resolved fluorescence Na
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[4CD44FF9A1FC]
http://linked.open...i/riv/nazevZdroje	Biochimica et Biophysica Acta - Biomembranes
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Interakce fluoresceinu a jeho analogů se sodno-draselnou pumpou. Progress and internationalization of biophysical research at Faculty of Science, Palacky University in Olomouc Nephrotoxicity of cisplatin – role of the Na+/K+-ATPase
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	1828
http://linked.open...iv/tvurceVysledku	Kubala, Martin Berka, Karel Havlíková, Marika Huličiak, Miroslav Bazgier, Václav
http://linked.open...ain/vavai/riv/wos	000315004600045
issn	0005-2736
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bbamem.2012.10.029
http://localhost/t...ganizacniJednotka	15310

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