| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - The tested complexes displayed a stronger cytotoxic effect against all the cancer cells as compared to cisplatin. The highest cytotoxicity was found for the complexes 4 (IC50 = 0.36 +- 0.05 mýM and 0.56 +- 0.15 mýM), 5 (IC50 = 0.66 +- 0.07 mýM and 0.73 +- 0.08 mýM) and 6 (IC50 = 0.57 +- 0.11 mýM and 0.70 +- 0.20 mýM) against A2780, and A2780cis respectively, as compared with the values of 12.0 +- 0.8 mýM and 27.0 +- 4.6 mýM determined for cisplatin. Moreover, the tested complexes were much less cytotoxic to primary human hepatocytes than to the cancer cells. The complexes 5 and 6 exhibited significantly high ability to modulate secretion of the pro-inflammatory cytokines TNF-alfa (2873 +- 238 pg/mL and 3284 +- 139 pg/mL for 5, and 6 respectively) and IL-1beta (1177 +- 128 pg/mL and 1087 +- 101 pg/mL for 5, and 6 respectively) tested on the lipopolysaccharide (LPS)-stimulated THP-1 cells as compared with the values of 1173 +- 85 pg/mL and 118.5 +- 4.8 pg/mL found for the commercially used anti-inflammatory drug prednisone. The ability of the tested complexes to interact with sulfur-containing biomolecules (cysteine and reduced glutathione) at physiological levels was proved by electrospray-ionization mass spectrometry.
- The tested complexes displayed a stronger cytotoxic effect against all the cancer cells as compared to cisplatin. The highest cytotoxicity was found for the complexes 4 (IC50 = 0.36 +- 0.05 mýM and 0.56 +- 0.15 mýM), 5 (IC50 = 0.66 +- 0.07 mýM and 0.73 +- 0.08 mýM) and 6 (IC50 = 0.57 +- 0.11 mýM and 0.70 +- 0.20 mýM) against A2780, and A2780cis respectively, as compared with the values of 12.0 +- 0.8 mýM and 27.0 +- 4.6 mýM determined for cisplatin. Moreover, the tested complexes were much less cytotoxic to primary human hepatocytes than to the cancer cells. The complexes 5 and 6 exhibited significantly high ability to modulate secretion of the pro-inflammatory cytokines TNF-alfa (2873 +- 238 pg/mL and 3284 +- 139 pg/mL for 5, and 6 respectively) and IL-1beta (1177 +- 128 pg/mL and 1087 +- 101 pg/mL for 5, and 6 respectively) tested on the lipopolysaccharide (LPS)-stimulated THP-1 cells as compared with the values of 1173 +- 85 pg/mL and 118.5 +- 4.8 pg/mL found for the commercially used anti-inflammatory drug prednisone. The ability of the tested complexes to interact with sulfur-containing biomolecules (cysteine and reduced glutathione) at physiological levels was proved by electrospray-ionization mass spectrometry. (en)
|
| Title
| - Cellular responses induced by Cu(II) quinolinonato complexes in human tumor and hepatic cells
- Cellular responses induced by Cu(II) quinolinonato complexes in human tumor and hepatic cells (en)
|
| skos:prefLabel
| - Cellular responses induced by Cu(II) quinolinonato complexes in human tumor and hepatic cells
- Cellular responses induced by Cu(II) quinolinonato complexes in human tumor and hepatic cells (en)
|
| skos:notation
| - RIV/61989592:15310/12:33143126!RIV13-MSM-15310___
|
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(ED2.1.00/03.0058), P(EE2.3.20.0017), S
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15310/12:33143126
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - Copper(II) complexes, In vitro cytotoxicity, Hepatotoxicity, Gene reporter assay, Inflammatory response, Quinolinone derivatives (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Chemistry Central Journal
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Dvořák, Zdeněk
- Hošek, Jan
- Trávníček, Zdeněk
- Vančo, Ján
- Buchtík, Roman
|
| http://linked.open...ain/vavai/riv/wos
| |
| issn
| |
| number of pages
| |
| http://bibframe.org/vocab/doi
| |
| http://localhost/t...ganizacniJednotka
| |
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