About: The Leaf Reticulate Mutant dov1 Is Impaired in the First Step of Purine Metabolism

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://mplant.oxfordjournals.org/content/5/6/1227
Description	A series of reticulated Arabidopsis thaliana mutants were previously described. All mutants show a reticulate leaf pattern, namely green veins on a pale leaf lamina. They have an aberrant mesophyll structure but an intact layer of bundle sheath cells around the veins. Here, we unravel the function of the previously described reticulated EMS-mutant dov1 (differential development of vascular associated cells 1). By positional cloning, we identified the mutated gene, which encodes glutamine phosphoribosyl pyrophosphate aminotransferase 2 (ATase2), an enzyme catalyzing the first step of purine nucleotide biosynthesis. dov1 is allelic to the previously characterized cia1-2 mutant that was isolated in a screen for mutants with impaired chloroplast protein import. We show that purine-derived total cytokinins are lowered in dov1 and crosses with phytohormone reporter lines revealed differential reporter activity patterns in dov1. Metabolite profiling unraveled that amino acids that are involved in purine biosynthesis are increased in dov1. This study identified the molecular basis of an established mutant line, which has the potential for further investigation of the interaction between metabolism and leaf development. A series of reticulated Arabidopsis thaliana mutants were previously described. All mutants show a reticulate leaf pattern, namely green veins on a pale leaf lamina. They have an aberrant mesophyll structure but an intact layer of bundle sheath cells around the veins. Here, we unravel the function of the previously described reticulated EMS-mutant dov1 (differential development of vascular associated cells 1). By positional cloning, we identified the mutated gene, which encodes glutamine phosphoribosyl pyrophosphate aminotransferase 2 (ATase2), an enzyme catalyzing the first step of purine nucleotide biosynthesis. dov1 is allelic to the previously characterized cia1-2 mutant that was isolated in a screen for mutants with impaired chloroplast protein import. We show that purine-derived total cytokinins are lowered in dov1 and crosses with phytohormone reporter lines revealed differential reporter activity patterns in dov1. Metabolite profiling unraveled that amino acids that are involved in purine biosynthesis are increased in dov1. This study identified the molecular basis of an established mutant line, which has the potential for further investigation of the interaction between metabolism and leaf development. (en)
Title	The Leaf Reticulate Mutant dov1 Is Impaired in the First Step of Purine Metabolism The Leaf Reticulate Mutant dov1 Is Impaired in the First Step of Purine Metabolism (en)
skos:prefLabel	The Leaf Reticulate Mutant dov1 Is Impaired in the First Step of Purine Metabolism The Leaf Reticulate Mutant dov1 Is Impaired in the First Step of Purine Metabolism (en)
skos:notation	RIV/61989592:15310/12:33142884!RIV13-AV0-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(KAN200380801), Z(AV0Z50380511)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Novák, Ondřej Strnad, Miroslav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	146631
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/12:33142884
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	purine metabolism; growth kinetics; cytokinin; reticulated mutants; leaf development (en)
http://linked.open.../riv/klicoveSlovo	cytokinin growth kinetics leaf development purine metabolism reticulated mutants
http://linked.open...odStatuVydavatele	CN - Čínská lidová republika
http://linked.open...ontrolniKodProRIV	[51F3F694832C]
http://linked.open...i/riv/nazevZdroje	Molecular Plant
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Immunonanotechnologies for hormone diagnostic
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Novák, Ondřej Strnad, Miroslav Braeutigam, Andrea Kanonenberg, Kerstin Mielewczik, Michael Nanda, Arun M Rosar, Christian Walter, Achim Weber, Andreas P. M.
http://linked.open...ain/vavai/riv/wos	000312573500010
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy
issn	1674-2052
number of pages	15 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/mp/sss045
http://localhost/t...ganizacniJednotka	15310

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