About: Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0039128X12002395
Description	Antiangiogenic activity of the brassinosteroid plant hormones (BRs) and their derivative cholestanon was investigated in human umbilical vein endothelial cells (HUVEC) and in human microvascular endothelial cells (HMEC-1). 24-Epibrassinolide and 28-homocastasterone from group of 21 tested natural BRs inhibited migration of HUVEC cells. Seven tested BRs decreased the number of tubes significantly. Synthetic analogue cholestanon inhibited angiogenesis in vitro more effectively than natural BRs. Because of the similarity of BRs to human steroids, we have also studied interactions of BRs with human steroid receptors. Synthetic BRs cholestanon showed agonistic effects on estrogen-receptor-alpha, estrogen-receptor-beta and androgen receptor. Of the natural BRs, 24-epibrassinolide was found to be a weak antagonist of estrogen-receptor-alpha (ER alpha). Our results provide the first evidence that large group of BRs can inhibit in vitro angiogenesis of primary endothelial cells. BRs constitute a novel group of human steroid receptor activators or inhibitors with capacity to inhibit angiogenesis. Antiangiogenic activity of the brassinosteroid plant hormones (BRs) and their derivative cholestanon was investigated in human umbilical vein endothelial cells (HUVEC) and in human microvascular endothelial cells (HMEC-1). 24-Epibrassinolide and 28-homocastasterone from group of 21 tested natural BRs inhibited migration of HUVEC cells. Seven tested BRs decreased the number of tubes significantly. Synthetic analogue cholestanon inhibited angiogenesis in vitro more effectively than natural BRs. Because of the similarity of BRs to human steroids, we have also studied interactions of BRs with human steroid receptors. Synthetic BRs cholestanon showed agonistic effects on estrogen-receptor-alpha, estrogen-receptor-beta and androgen receptor. Of the natural BRs, 24-epibrassinolide was found to be a weak antagonist of estrogen-receptor-alpha (ER alpha). Our results provide the first evidence that large group of BRs can inhibit in vitro angiogenesis of primary endothelial cells. BRs constitute a novel group of human steroid receptor activators or inhibitors with capacity to inhibit angiogenesis. (en)
Title	Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells (en)
skos:prefLabel	Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells Brassinosteroids inhibit in vitro angiogenesis in human endothelial cells (en)
skos:notation	RIV/61989592:15310/12:33142882!RIV13-MSM-15310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ED0007/01/01), P(GA301/08/1649), P(LC06077), Z(AV0Z40550506), Z(AV0Z50380511), Z(AV0Z50520514)
http://linked.open...iv/cisloPeriodika	13
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kryštof, Vladimír Strnad, Miroslav Rárová, Lucie Kohout, Ladislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	125487
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/12:33142882
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Receptors; Natural products; Migration; Human umbilical vein endothelial cells; Angiogenesis (en)
http://linked.open.../riv/klicoveSlovo	Angiogenesis Human umbilical vein endothelial cells Natural products Receptors Migration
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[B81B16C6C95D]
http://linked.open...i/riv/nazevZdroje	Steroids
http://linked.open...in/vavai/riv/obor	ED
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre of the Region Haná for Biotechnological and Agricultural Research Modulation of cell division of normal and cancer cells by cyclin-dependent kinase inhibitors Center of Chemical Genetics
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	77
http://linked.open...iv/tvurceVysledku	Bartůněk, Petr Kohout, Ladislav Kryštof, Vladimír Strnad, Miroslav Rárová, Lucie Sedlák, David Liebl, Johanna Zahler, Stefan
http://linked.open...ain/vavai/riv/wos	000312423300024
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů
issn	0039-128X
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.steroids.2012.08.011
http://localhost/t...ganizacniJednotka	15310

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