About: Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes

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About: Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0968089612008231
Description	Sixteen platinum(II) complexes of estrone and estradiol were synthesized in this work to evaluate their cytotoxic activity against several cancer cell lines including estrogen dependent and independent ones. The synthesis of all the complexes was done in three steps. The reaction of steroids with dibromoalkanes was followed by a reaction of the bromoalkyl steroids with 2-(aminomethyl) pyridine or 2-(2-aminoethyl) pyridine. The last step was a reaction of steroidal diamino ligands with potassium tetrachloroplatinate to obtain the desired platinum(II) complexes. Cytotoxicity assays showed that most of the complexes prepared are active against the cancer cell lines used-CEM, U-2 OS, MCF7, MCF7 AL, MDA-MB-468, BT-474, BT-549, and BJ fibroblasts. The six-membered platinum complexes are more active than five-membered ones. Sixteen platinum(II) complexes of estrone and estradiol were synthesized in this work to evaluate their cytotoxic activity against several cancer cell lines including estrogen dependent and independent ones. The synthesis of all the complexes was done in three steps. The reaction of steroids with dibromoalkanes was followed by a reaction of the bromoalkyl steroids with 2-(aminomethyl) pyridine or 2-(2-aminoethyl) pyridine. The last step was a reaction of steroidal diamino ligands with potassium tetrachloroplatinate to obtain the desired platinum(II) complexes. Cytotoxicity assays showed that most of the complexes prepared are active against the cancer cell lines used-CEM, U-2 OS, MCF7, MCF7 AL, MDA-MB-468, BT-474, BT-549, and BJ fibroblasts. The six-membered platinum complexes are more active than five-membered ones. (en)
Title	Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes (en)
skos:prefLabel	Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes Synthesis and cytotoxic activities of estrone and estradiol cis-dichloroplatinum(II) complexes (en)
skos:notation	RIV/61989592:15310/12:33142805!RIV13-MSM-15310___
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(1M06030), P(ED0007/01/01), P(IAA400550801)
http://linked.open...iv/cisloPeriodika	24
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Oklešťková, Jana Kvasnica, Miroslav Rárová, Lucie Kohout, Ladislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Palackého v Olomouci / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	172929
http://linked.open...ai/riv/idVysledku	RIV/61989592:15310/12:33142805
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cytotoxicity; Platinum complex; Estradiol; Estrone; Steroids (en)
http://linked.open.../riv/klicoveSlovo	Estradiol Steroids Cytotoxicity Estrone Platinum complex
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A38267FEE39E]
http://linked.open...i/riv/nazevZdroje	Bioorganic & Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	CC
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Synthesis of tritium labelled brassinosteroids and their application in the studies of their mechanism of action on molecular level. Functional genomics and proteomics for crop improvement Centre of the Region Haná for Biotechnological and Agricultural Research
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	20
http://linked.open...iv/tvurceVysledku	Buděšínský, Miloš Kohout, Ladislav Rárová, Lucie Oklešťková, Jana Kvasnica, Miroslav
http://linked.open...ain/vavai/riv/wos	000311421300008
issn	0968-0896
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.bmc.2012.10.013
http://localhost/t...ganizacniJednotka	15310

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